Results 221 to 230 of about 145,467 (273)

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.
Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana, Aleksandr V. Sokolov, Helgi B. Schiöth, Viswanathan Mohan, Xiao Tan   +8 more
wiley   +1 more source

Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study

Fundamental &Clinical Pharmacology, Volume 39, Issue 6, December 2025.
ABSTRACT Background Direct‐acting oral anticoagulants (DOACs) have largely replaced warfarin for stroke prevention in patients with atrial fibrillation, yet their population‐level impact on health outcomes and costs remains unclear. We examined whether the widespread uptake of DOACs was associated with changes in hospitalization rates and costs for ...
Tony Antoniou, Daniel McCormack, Tianru Wang, Mina Tadrous, Tara Gomes   +4 more
wiley   +1 more source

Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Introduction Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to
Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier   +17 more
wiley   +1 more source

Comparative effectiveness of direct oral anticoagulants and warfarin for the treatment of left ventricular thrombus

Journal of Thrombosis and Thrombolysis, 2019
M. E. Bass, T. Kiser, R. Page, C. McIlvennan, L. Allen, Garth Wright, C. Shakowski   +6 more
semanticscholar   +1 more source

Trends and Outcomes of Anticoagulation for Post‐Operative Atrial Fibrillation After Coronary Artery Bypass Graft

Pacing and Clinical Electrophysiology, Volume 48, Issue 12, Page 1444-1450, December 2025.
ABSTRACT Background The benefit of oral anticoagulation (OAC) in patients with new‐onset postoperative atrial fibrillation (POAF) after coronary bypass grafting remains uncertain. The 2023 American Heart Association (AHA) and the American College of Cardiology (ACC) guidelines recommend 60 days of anticoagulation for POAF, whereas management was ...
Daniel S. Cheah, Kathryn Tsai, Krishna Prasad Kurpad, Yousra Khalid, Sanjay S. Mehta   +4 more
wiley   +1 more source

Letter by David et al Regarding Article, “Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin: Results From the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Randomized Trial” [PDF]

, 2013
Jean David, Vincent Piriou, Pierre Albaladejo   +2 more
openalex   +1 more source

Elderly Medical Patients' Experience of an Acute Readmission to the Emergency Department—An Interpretative Phenomenological Analysis

Scandinavian Journal of Caring Sciences, Volume 39, Issue 4, December 2025.
ABSTRACT Aims and Objectives To explore the experiences of elderly medical patients shortly after an unplanned emergency department readmission and the perceived value of health care encounters. Background Elderly medical patients are often frail, have multiple health issues and are at risk for (re)admissions, loss of function, morbidity, and mortality.
Sara Levi Hemmingsen, Pernille Würtz Bøhm, Janet Froulund Jensen, Jeanette Wassar Kirk, Tom Møller   +4 more
wiley   +1 more source

Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.

New England Journal of Medicine, 2005
M. Chimowitz, M. Lynn, Harriet Howlett-Smith, B. Stern, V. Hertzberg, Michael R. Frankel, S. Levine, S. Chaturvedi, S. Kasner, C. Benesch, C. Sila, T. Jovin, J. Romano   +12 more
semanticscholar   +1 more source

Safety evaluation of jagua (genipin‐glycine) blue as a food additive

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety of jagua (genipin‐glycine) blue as a new food additive. Jagua (genipin‐glycine) blue is obtained by water extraction of the ground pulp of the peeled, unripe fruits of Genipa americana L.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, José Manuel Barat Baviera, Gisela Degen, David Gott, Jean‐Charles Leblanc, Peter Moldeus, Ine Waalkens‐Berendsen, Detlef Wölfle, Consuelo Civitella, Agnieszka Mech, Concepción Medrano‐Padial, Alexandra Tard, Panagiota Zakidou, Laura Ruggeri   +29 more
wiley   +1 more source

Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation

Journal of the American Medical Association (JAMA), 2017
W. Lau, E. Chan, C. Cheung, C. Sing, K. Man, G. Lip, C. Siu, J. Lam, Alan C H Lee, I. Wong   +9 more
semanticscholar   +1 more source