Results 61 to 70 of about 1,496,873 (279)

CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection

Cell Reports, 2023
Summary: Infections cause catabolism of fat and muscle stores. Traditionally, studies have focused on understanding how the innate immune system contributes to energy stores wasting, while the role of the adaptive immune system remains elusive.
Samuel E. Redford, Siva Karthik Varanasi, Karina K. Sanchez, Natalia R. Thorup, Janelle S. Ayres   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Emerging Infectious Diseases, 2018
Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway.
L. Pirisinu, L. Tran, B. Chiappini, I. Vanni, M. D. Di Bari, G. Vaccari, T. Vikøren, K. Madslien, Jørn Våge, T. Spraker, G. Mitchell, A. Balachandran, T. Baron, C. Casalone, C. Rolandsen, K. Røed, U. Agrimi, R. Nonno, S. Benestad   +18 more
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

International Journal of Nephrology and Renovascular Disease, 2020
Chaltu Merga,1 Meron Girma,2 Melese Sinaga Teshome2 1Department of Nutrition, Ambo University, Ambo, Ethiopia; 2Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, EthiopiaCorrespondence: Melese ...
Merga C, Girma M, Teshome MS
doaj  

The Effect of Chronic Wasting Disease on Resident Deer Hunting Permit Demand in Wisconsin

Animals, 2019
Simple Summary Chronic wasting disease is a fatal neurodegenerative disease that affects cervids across the world. While chronic wasting disease is not known to be transmissible to humans, there is increasing concern about chronic wasting disease risks ...
D. Erickson, Carson J. Reeling, John G. Lee   +2 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Human Prion Disease and Relative Risk Associated with Chronic Wasting Disease

Emerging Infectious Diseases, 2006
The transmission of the prion disease bovine spongiform encephalopathy (BSE) to humans raises concern about chronic wasting disease (CWD), a prion disease of deer and elk. In 7 Colorado counties with high CWD prevalence, 75% of state hunting licenses are
W. John Pape, Jeri Forster, C. Alan Anderson, Patrick Bosque, Patrick Bosque, Michael Miller   +5 more
doaj   +1 more source

Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. [PDF]

PLoS ONE, 2016
Chronic wasting disease (CWD) is an invariably fatal transmissible spongiform encephalopathy of white-tailed deer, mule deer, elk, and moose. Despite a 100% fatality rate, areas of high prevalence, and increasingly expanding geographic endemic areas ...
David R Edmunds, Matthew J Kauffman, Brant A Schumaker, Frederick G Lindzey, Walter E Cook, Terry J Kreeger, Ronald G Grogan, Todd E Cornish   +7 more
doaj   +1 more source