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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Sorption characteristics of fermented cocoa powder (Theobroma cacao)</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista Técnica de la Facultad de Ingeniería</i>, 2002 </span><br><span class="r_content">Se determinaron experimentalmente las isotermas de sorción de cacao fermentado de grado fino de primera (Theobroma cacao), en el rango de temperaturas de 5°C a 30°C y se ajustaron a diversas ecuaciones de isotermas de sorción, con el fin de obtener la ...</span><br><span class="r_sub"><i>Aleida J Sandoval<span id="ma_4" style="display:none">, José A Barreiro, Xiomara Tovar, Mercedes Angueira</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_4')">+3 more</a></small></i></span><br><small><a href="https://doaj.org/article/e45e5b9db4034b02a7062f192d537deb" target="_blank" rel="nofollow" title="doaj.org/article/e45e5b9db4034b02a7062f192d537deb">doaj</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3390/foods12214018" target="_blank" rel="nofollow">Dynamics of Active Fluorescent Units (AFU) and Water Activity (a<sub>w</sub>) Changes in Probiotic Products-Pilot Study.</a> <b><a href="https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10647652&blobtype=pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Foods</i>, 2023 </span><br><span class="r_sub"><i>Sielatycka K<span id="ma_5" style="display:none">, Śliwa-Dominiak J, Radaczyńska M, Juzwa W, Kaczmarczyk M, Marlicz W, Skonieczna-Żydecka K, Łoniewski I.</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+7 more</a></small></i></span><br><small><a href="https://europepmc.org/article/MED/37959137#free-full-text" target="_blank" rel="nofollow" title="europepmc.org/article/MED/37959137#free-full-text">europepmc</a> </small>   <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.3390%2Ffoods12214018" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3390/foods12214018'); alert('Copied the doi');">copy doi</a> <small>(10.3390/foods12214018)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1021/jm00017a020" target="_blank" rel="nofollow">The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: green" title="open access: green" width="16" height="16">, 1995 </span><br><span class="r_sub"><i>Vincent Mikol<span id="ma_6" style="display:none">, Christos Papageorgiou, Xaver Borer</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+2 more</a></small></i></span><br><small><a href="https://openalex.org/W2000755562" target="_blank" rel="nofollow" title="openalex.org/W2000755562">openalex</a> </small>   <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1021%2Fjm00017a020" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1021/jm00017a020'); alert('Copied the doi');">copy doi</a> <small>(10.1021/jm00017a020)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://core.ac.uk/download/pdf/6279261.pdf" target="_blank" rel="nofollow">Socioeconomic Factors and Water Quality in California</a> <b><a href="http://www.feem.it/userfiles/attach/2011781234534NDL2011-051.pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"></span><br><span class="r_content">We investigate the relationships between water quality and socioeconomic factors in California at the county level for the years 1993 to 2006 using 24 water quality indicators coming from seven different types of water bodies.</span><br><span class="r_sub"><i>Kelly A. Grogan, Y. Hossein Farzin</i></span><br><small><a href="https://core.ac.uk/works/2484676" target="_blank" rel="nofollow" title="core.ac.uk/works/2484676">core</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70189" target="_blank" rel="nofollow">Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.</span><br><span class="r_sub"><i>Veera K. Ojala<span id="ma_8" style="display:none">, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+15 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70189?mi=2or9o2m&af=R&AllField=water activity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70189?mi=2or9o2m&af=R&AllField=water activity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70189" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70189'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70189)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70191" target="_blank" rel="nofollow">Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve </span><br><span class="r_sub"><i>Hsu‐Min Sung<span id="ma_9" style="display:none">, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+17 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70191?mi=2or9o2m&af=R&AllField=water activity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70191?mi=2or9o2m&af=R&AllField=water activity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70191" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70191'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70191)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3390/foods12203751" target="_blank" rel="nofollow">Effect of Water Activity, pH, and Lactic Acid Bacteria to Inhibit <i>Escherichia coli</i> during Chihuahua Cheese Manufacture.</a> <b><a href="https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10606664&blobtype=pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Foods</i>, 2023 </span><br><span class="r_sub"><i>Chacón-Flores NA<span id="ma_10" style="display:none">, Olivas-Orozco GI, Acosta-Muñiz CH, Gutiérrez-Méndez N, Sepúlveda-Ahumada DR.</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+4 more</a></small></i></span><br><small><a href="https://europepmc.org/article/MED/37893643#free-full-text" target="_blank" rel="nofollow" title="europepmc.org/article/MED/37893643#free-full-text">europepmc</a> </small>   <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.3390%2Ffoods12203751" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3390/foods12203751'); alert('Copied the doi');">copy doi</a> <small>(10.3390/foods12203751)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-chemistry/" class="suggestion"onclick="show_loader();"><b>chemistry</b></a><br/><a href="/q-biology/" class="suggestion"onclick="show_loader();"><b>biology</b></a><br/><a href="/q-environmental_science/" class="suggestion"onclick="show_loader();"><b>environmental science</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-medicine/" class="suggestion"onclick="show_loader();"><b>medicine</b></a><br/><a href="/q-organic_chemistry/" class="suggestion"onclick="show_loader();"><b>organic chemistry</b></a><br/><a href="/q-biochemistry/" class="suggestion"onclick="show_loader();"><b>biochemistry</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-6._clean_water/" class="suggestion"onclick="show_loader();"><b>6. clean water</b></a><br/><a href="/q-physics/" class="suggestion"onclick="show_loader();"><b>physics</b></a><br/><a href="/q-engineering/" class="suggestion"onclick="show_loader();"><b>engineering</b></a><br/></div></div></div><div class="pagenav"><a href="/q-water_activity/p-15/" rel="nofollow"><b>previous</b></a>   <a href="/q-water_activity/p-14/" rel="nofollow">14</a>  <a href="/q-water_activity/p-15/" rel="nofollow">15</a>  <b>16</b>  <a href="/q-water_activity/p-17/" rel="nofollow">17</a>  <a href="/q-water_activity/p-18/" rel="nofollow">18</a>   <a href="/q-water_activity/p-17/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>