Results 51 to 60 of about 677,925 (163)

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Polo-like kinase-1, Aurora kinase A and WEE1 kinase are promising druggable targets in CML cells displaying BCR::ABL1-independent resistance to tyrosine kinase inhibitors

Frontiers in Oncology, 2022
In chronic myeloid leukemia (CML), Aurora kinase A and Polo like kinase 1 (PLK1), two serine-threonine kinases involved in the maintenance of genomic stability by preserving a functional G2/M checkpoint, have been implicated in BCR::ABL1-independent ...
Manuela Mancini, Sara De Santis, Cecilia Monaldi, Fausto Castagnetti, Fausto Castagnetti, Annalisa Lonetti, Samantha Bruno, Elisa Dan, Barbara Sinigaglia, Barbara Sinigaglia, Gianantonio Rosti, Michele Cavo, Michele Cavo, Gabriele Gugliotta, Simona Soverini   +14 more
doaj   +1 more source

Molecular Links Between Heat Stress and DNA Damage Response in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach, Miriam Szurman‐Zubrzycka   +1 more
wiley   +1 more source

XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib

Therapeutic Advances in Medical Oncology, 2020
Background: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy.
Reem Ali, Adel Alblihy, Michael S. Toss, Mashael Algethami, Rabab Al Sunni, Andrew R. Green, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, Volume 143, Issue 41, November 5, 2026.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression

, 2023
Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of DNA-damaging agents. AZD1775 is a nonselective Wee1 inhibitor for
Bayard Huck (11512135), Stephanie Simon, Ruoxi Lan (11512138), Zhuo Zhang, Christian Sirrenberg, Brian Sherer, Satenig Guler (2019832), Zhuo Zhang (72795), Benjamin Doerfel (12969456), Maria C. DiPoto (15197259), Heike Schilke, Richard Caldwell (1405651), Christian Sirrenberg (483562), Alejandro Crespo (1445995), Nina Grossmann (15197262), Christopher CV Jones (15197265), Heike Schilke (11267557), Maria C. DiPoto, Djordje Musil (483563), Brian Sherer (7251149), Justin Potnick, Justin Potnick (11512141), Lesley Liu-Bujalski (7251155), Kevin Ho (135900), Kevin Ho, Christopher CV Jones, Richard Caldwell, Lesley Liu-Bujalski, Benjamin Doerfel, Djordje Musil, Nina Grossmann, Ruoxi Lan, Alejandro Crespo, Bayard Huck, Stephanie Simon (4181320), Satenig Guler   +35 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status

, 2022
OBJECTIVE: Oral tongue squamous cell carcinoma (OTSCC) frequently harbors non-functional p53 and depends on G2/M checkpoint mediated by WEE1. WEE1 suppression has been identified as a promising anti-tumor strategy. This study investigated the capacity of
Sminia, Peter, Tymour Forouzanfar, Doulabi, Behrouz Zandieh, Aisha Hussein Al‐Jamaei, de Visscher, Jan G.A.M., Al-Jamaei, Aisha Hussein, Peter Sminia, Marco N. Helder, Jan G. A. M. de Visscher, Subramanyam, V. Ramadugula, V. Ramadugula Subramanyam, Behrouz Zandieh Doulabi, Helder, Marco N., Forouzanfar, Tymour   +13 more
core   +1 more source

Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors

Frontiers in Oncology, 2020
Dysfunctional DNA repair with subsequent genome instability and high mutational burden represents a major hallmark of cancer. In established malignant tumors, increased DNA repair capacity mediates resistance to DNA-damaging therapeutics, including ...
Mariam Gachechiladze, Josef Skarda, Katerina Bouchalova, Alex Soltermann, Markus Joerger   +4 more
doaj   +1 more source

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source