Results 71 to 80 of about 677,925 (163)
Advanced Science, Volume 13, Issue 51, 14 September 2026.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Wee1-Hsp90 inhibitor combination treatment [PDF]
Cell Cycle, 2012 Pharmacological inhibition of molecular chaperone Hsp90 is an attractive approach for anticancer therapy, since the chaperone activity of Hsp90 is critical for the stability and activity of a variety of cellular client proteins. The list of Hsp90 client proteins is always expanding and includes transcription factors, steroid hormone receptors, protein ...
openaire +2 more sources
BMEMat, Volume 4, Issue 3, September 2026.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Summary of WEE1 inhibitor adavosertib clinical ...
Samuel Abbou (15119500) +22 more
core +1 more source
Journal of Applied Toxicology, Volume 46, Issue 9, Page 3164-3176, September 2026.ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito +11 more
wiley +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Jonathan Cunningham
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
Cell size–dependent regulation of Wee1 localization by Cdr2 cortical nodes
, 2018 Cell size control requires mechanisms that link cell growth with Cdk1 activity. In fission yeast, the protein kinase Cdr2 forms cortical nodes that include the Cdk1 inhibitor Wee1 along with the Wee1-inhibitory kinase Cdr1.
Uche Medoh +4 more
core +1 more source
Introduction to Single‐Cell Physiologically‐Based Pharmacokinetic (scPBPK) Models
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.ABSTRACT The current investigation introduces single‐cell physiologically based pharmacokinetic (scPBPK) models to gain insight into drug disposition at the cellular scale. The transition from standard PBPK (sPBPK) models to scPBPK models required depiction of expression‐dependent (ED) processes, such as drug metabolism or membrane transport.
Anshul Saini, James M. Gallo
wiley +1 more source
Signal Transduction and Targeted TherapyMetabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets.
Hyeon-Ji Kim +13 more
doaj +1 more source