Results 81 to 90 of about 677,925 (163)

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Protein expression of WEE1 and PARP1 in DLBCL and in in vitro killing assays.

, 2018
(A) Western blot results for Wee1, PARP1 in eight DLBCL cell lines. Two LCL cell lines are shown as normal B-cell controls. (B) Immunohistochemistry of Wee1 (left column) and PARP1 (right column) on DLBCL patient samples.
Rozemarijn S. van Rijn (4898842), Gerwin Huls (3371285), Arjan Diepstra (151995), Emanuele Ammatuna (4898836), Rudolf S. N. Fehrmann (87558), Edo Vellenga (256890), Mathilde R. W. de Jong (4898845), Tom van Meerten (4898833), Lydia Visser (151980), Marcel van Vugt (4898839), Anke van den Berg (80131)   +10 more
core   +1 more source

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

, 2015
Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry.
Roush, William R, Penas, Clara, Ayad, Nagi G, Mishra, Jitendra K, Wood, Spencer D, Schürer, Stephan C   +5 more
core   +2 more sources

C/EBPβ Is a Transcriptional Regulator of Wee1 at the G₂/M Phase of the Cell Cycle

Cells, 2019
The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that regulates cellular proliferation, differentiation, apoptosis and tumorigenesis.
Ji Hae Lee, Jee Young Sung, Eun Kyung Choi, Hyun-Kyoung Yoon, Bo Ram Kang, Eun Kyung Hong, Byung-Kiu Park, Yong-Nyun Kim, Seung Bae Rho, Kyungsil Yoon   +9 more
doaj   +1 more source

Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia

, 2019
Introduction: Screening for synthetic lethality markers has demonstrated that the inhibition of the cell cycle checkpoint kinases WEE1 together with CHK1 drastically affects stability of the cell cycle and induces cell death in rapidly proliferating ...
Giovanni Marconi, Timothy J. Yen, Enrica Imbrogno, Andrea Ghelli Luserna Di Rorà, Stefania Paolini, Carolina Terragna, Giorgia Simonetti, Valentina Robustelli, Anna Ferrari, Cristina Papayannidis, Samantha Bruno, Matteo Bocconcelli, Gabriella Chirumbolo, Martina Ghetti, Neil Beeharry, Giovanni Martinelli, Roberta Napolitano, Chiara Sartor   +17 more
core   +2 more sources

SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity

Advanced Science, 2020
High‐throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers. However, the heritability of a substantial proportion of cancers remains unexplained, which may result from rare deleterious ...
Miao Li, Hongwu Wang, Hongwei Liao, Jiaxin Shen, Yinfang Wu, Yanping Wu, Qingyu Weng, Chen Zhu, Xinwei Geng, Fen Lan, Yang Xia, Bin Zhang, Hang Zou, Nan Zhang, Yunzhi Zhou, Zhihua Chen, Huahao Shen, Songmin Ying, Wen Li   +18 more
doaj   +1 more source

Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant Concentrations

, 2019
Wee1 kinase is an inhibitor of cyclin-dependent kinase (cdk)s, crucial cell cycle progression drivers. By phosphorylating cdk1 at tyrosine 15, Wee1 inhibits activation of cyclin B-cdk1 (Cdk1), preventing cells from entering mitosis with incompletely ...
Luca Nardella, D'alterio G, Serpico AF, Rosa Della Monica, Monica RD, Nardella L, Giuseppe D’Alterio, Angela Flavia Serpico, Visconti R, Roberta Visconti, Grieco D, Vetrei C, Cinzia Vetrei, Domenico Grieco   +13 more
core   +2 more sources

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Journal for ImmunoTherapy of Cancer, 2018
Background Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes.
Jay Friedman, Megan Morisada, Lillian Sun, Ellen C. Moore, Michelle Padget, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro, Clint T. Allen   +8 more
doaj   +1 more source

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2018
Background Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases.
Andrea Ghelli Luserna Di Rorà, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara Abbenante, Giovanni Marconi, Stefania Paolini, Sarah Parisi, Chiara Sartor, Maria Chiara Fontana, Serena De Matteis, Ilaria Iacobucci, Pier Giuseppe Pelicci, Michele Cavo, Timothy J. Yen, Giovanni Martinelli   +23 more
doaj   +1 more source

Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation

The signaling complex around voltage-gated sodium (Nav) channels includes accessory proteins and kinases crucial for regulating neuronal firing. Previous studies showed that one such kinase, WEE1—critical to the cell cycle—selectively ...
Aditya K. Singh, Fernanda Laezza, Nana A. Goode, Jully Singh   +3 more
core   +1 more source