Results 91 to 100 of about 677,925 (163)

Wee1 inhibitor PD0166285 sensitized TP53 mutant lung squamous cell carcinoma to cisplatin via STAT1

Cancer Cell International
Background Lung squamous cell carcinoma (LUSCs) is associated with high mortality (20–30%) and lacks of effective treatments. Almost all LUSC exhibit somatic mutations in TP53. Wee1, a tyrosine kinase, regulates the cell cycle at the G2/M checkpoint.
Qi Li, Wenjie Yang, Qingyi Zhang, Daoming Zhang, Jun Deng, Binxin Chen, Ping Li, Huanqi Zhang, Yiming Jiang, Yangling Li, Bo Zhang, Nengming Lin   +11 more
doaj   +1 more source

Targeting WEE1 and asciminib suppresses ABL-tyrosine kinase inhibitor-resistant chronic myeloid leukemia cells

Discover Oncology
Background Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the uncontrolled proliferation of white blood cells. Tyrosine kinase inhibitors (TKIs) are the standard treatment; however, resistance to BCR::ABL1 mutations ...
Seiichi Okabe, Mitsuru Moriyama, Akihiko Gotoh, Daigo Akahane   +3 more
doaj   +1 more source

GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

Cell Reports
Summary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity.
Alexandros P. Drainas, Wen-Hao Hsu, Alec E. Dallas, Carson D. Poltorack, Jun W. Kim, Andy He, Garry L. Coles, Maya Baron, Michael C. Bassik, Julien Sage   +9 more
doaj   +1 more source

Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons

Cell Death and Disease
Ionising radiation causes the introduction of DNA damage, more specifically double strand breaks (DSBs) and complex DNA damage (CDD), that induces cancer cell death leading to the therapeutic effect.
Emma Melia, Anne-Sophie Fisch, Ingeborg Tinhofer, Jason L. Parsons   +3 more
doaj   +1 more source

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma

iScience
Summary: Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic TP53 mutation and increased risk of cancer development, including Sonic Hedgehog-activated medulloblastoma (SHH-MB).
Anna S. Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty, Jürgen Burhenne, Shunya Ohmura, Tim Holland-Letz, Lena M. Kutscher, Aurélie Ernst, Pei-Chi Wei, Thomas G.P. Grünewald, Ina Oehme, Marcel Kool, David T.W. Jones, Kristian W. Pajtler, Christian P. Kratz, Stefan M. Pfister, Olaf Witt, Till Milde   +24 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.

, 2010
SummaryKinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene expression profiles of various tumor types and reveal the wee1 kinase to be ...
Krawczyk, P.M., An Claes, Aten, J.A., Dirk Geerts, Cloos, J., Angela A.G. Van Tilborg, Leonora Balaj, Kaspers, G.J.L., Tilborg, A.A. Van, Wesseling, P., Jacqueline Cloos, Jacob A. Aten, Balaj, L., Przemek M. Krawczyk, Bakhos A. Tannous, Johanna M. Niers, Pieter Wesseling, Gertjan J.L. Kaspers, De Witt Hamer, P.C., Claes, A., Aeilko H. Zwinderman, W. Peter Vandertop, Thomas Würdinger, David P. Noske, Shahryar E. Mir, Cornelis J.F. Van Noorden, Philip C. De Witt Hamer, Vandertop, W.P., Tannous, B.A., Mir, S.E., Geerts, D., Zwinderman, A.H., Noske, D.P., Noorden, C.J.F. van, Niers, J.M., Wurdinger, T.   +35 more
core   +1 more source

Phase 2 study of Wee1 inhibitor adavosertib in recurrent uterine carcinosarcoma

Gynecologic Oncology Reports
Uterine carcinosarcoma (UCS) is a rare but aggressive tumor with high rates of recurrence and poor prognosis, and novel therapies are urgently needed. P53 mutations are identified in over 90% of cases, and other cell cycle alterations are commonly found indicating potential vulnerability to Wee1 kinase inhibition.
Stephanie Cham, Niya Xiong, Nabihah Tayob, Carolyn Krasner, Alexi A. Wright, Elizabeth K. Lee, Hannah Sawyer, Cara Mathews, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Joyce F. Liu   +10 more
openaire   +3 more sources

Preclinical evaluation of the antitumoral efficacy of Wee1 inhibitor AZD1775 in adrenocortical carcinoma

Pharmacological Research
Current therapy for advanced adrenocortical carcinoma (ACC) is represented by EDP-M (etoposide, doxorubicin, cisplatin + mitotane), but its efficacy is limited and new approaches are needed. Our previous in vitro findings showed that AZD1775, an inhibitor of the G2/M checkpoint gatekeeper Wee1, reduces proliferation and increases apoptosis in ACC cell ...
Nozza Emma, Esposito Emanuela, Di Muro Genesio, Di Bari Sonia, Catalano Rosa, Lopez Gianluca, Vaira Valentina, Anna Maria Barbieri, Marra Giusy, Mangili Federica, Treppiedi Donatella, Battistin Michele, Di Dalmazi Guido, Palmieri Serena, Ferrante Emanuele, Mantovani Giovanna, Peverelli Erika   +16 more
openaire   +4 more sources

Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas [PDF]

Filamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA). Its presence is associated to a less aggressive tumour behaviour, potentially due to its role in negatively regulating IGF1R signalling.
Maioli, Sara; https://orcid.org/, Ferrante, Emanuele; https://orcid.org/, Baldari, Ludovica; https://orcid.org/, Mantovani, Giovanna; https://orcid.org/, Di Dalmazi, Guido; https://orcid.org/, Sigala, Sandra; https://orcid.org/, Berruti, Alfredo; https://orcid.org/, Peverelli, Erika; https://orcid.org/, Nozza, Emma; https://orcid.org/, Marra, Giusy; https://orcid.org/, Esposito, Emanuela; https://orcid.org/, Mangone, Alessandra; https://orcid.org/, Geginat, Jens; https://orcid.org/, Hantel, Constanze; https://orcid.org/, Cassinotti, Elisa; https://orcid.org/, Catalano, Rosa; https://orcid.org/, Barbieri, Anna Maria; https://orcid.org/, Palmieri, Serena; https://orcid.org/   +17 more
core   +1 more source