Results 101 to 110 of about 677,925 (163)

Wee1 Inhibitor AZD1775 Combined with Cisplatin Potentiates Anticancer Activity against Gastric Cancer by Increasing DNA Damage and Cell Apoptosis

, 2018
Based on the mechanisms by which Wee1 inhibitor and cisplatin played their own role, a promising strategy of Wee1 inhibitor combined with cisplatin was proposed, which was investigated in gastric cancer (GC).
Dongshao Chen, Zhongwu Li, Xiaotian Zhang, Cheng Zhang, Jing Gao, Bin Dong, Xiaoting Lin, Lin Shen   +7 more
core   +1 more source

Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1

Clinics, 2013
OBJECTIVES: MiRNAs are intrinsic RNAs that interfere with protein translation. Few studies on the synergistic effects of miRNAs have been reported. Both miR-424 and miR-381 have been individually reported to be involved in carcinogenesis.
Binghai Chen, Lujing Duan, Guangming Yin, Jing Tan, Xianzhen Jiang   +4 more
doaj  

Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells

BMC Cancer
Background Ewing’s sarcoma is a childhood bone and soft tissue cancer with poor prognosis. Treatment outcomes for Ewing’s sarcoma patients have improved only modestly over the past decades, making the development of new treatment strategies paramount. In
Judy Ziener, Julián Andrés Henao-Restrepo, Johanna Leonhardi, Max-Johann Sturm, Sabine Becker, Diana M. Morales-Prieto, Till Milde, James F. Beck, Jürgen Sonnemann   +8 more
doaj   +1 more source

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells

, 2016
The current treatment for medulloblastoma includes surgical resection, radiation, and cytotoxic chemotherapy. Although this approach has improved survival rates, the high doses of chemotherapy required for clinical efficacy often result in lasting ...
Michael F. Wempe (339637), Vladimir Amani (1443661), Donald S. Backos (1443664), Sujatha Venkataraman (194808), Nicholas K. Foreman (1443667), Christopher J. Matheson (1443670), Philip Reigan (159804), Peter S. Harris (351495), Andrew M. Donson (1443673), Rajeev Vibhakar (247074)   +9 more
core   +1 more source

Comprehensive multi-omics analyses expose a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition

Journal of Advanced Research
Introduction: Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignancy with a poor prognosis, highlighting the need to target specific vulnerabilities within the tumor during treatment.
Xing Jia, Xingxin Zhu, Shinuo Chen, Qiongzi Qiu, Wenfeng Song, Shiyu Zhang, Haijiang Dong, Zequn Li, Suchen Bian, Hao Wu, Haojiang Dai, Cheng Jin, Mengqiao Zhou, Jun Chen, Zefeng Xuan, Pengfei Liu, Qiufang Zeng, Haiyang Xie, Shusen Zheng, Penghong Song   +19 more
doaj   +1 more source

Supplemenatry Figure S7 from PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer

, 2016
(A) TMA2 WEE1 and PAXIP1 staining, breakdown by KRAS mutation and WEE1/PAXIP1 staining status. (B) TMA3 - WEE1 and PAXIP1 staining.
Eric B. Haura (239755), Nicholas T. Woods (7321022), Uwe Rix (236984), Ankita Jhuraney (15074326), Alvaro N. Monteiro (3825559), Lily Rix (15074329), W. Douglas Cress (10987635), Fumi Kinose (846843), Gabriela Wright (237756), Elizabeth Remily-Wood (1843075), Jhanelle E. Gray (4094155), Stephen G. Brantley (15074335), John M. Koomen (228649), Jodi L. Kroeger (15074332)   +13 more
core   +1 more source

Investigation into Sustainability of WEE1 Kinase in Plants

Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase.
Cook, Gemma S.
core   +2 more sources

Investigation into the stability of WEE1 kinase in plants [PDF]

Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase.
Cook, Gemma S.
core  

Ferroptosis synergistically sensitizes wee1 inhibitors: a bibliometric study.

American journal of translational research
Synthetic lethality (SL) is a lethal phenomenon with an important role in cancer treatment. This study was conducted to analyze the hotspots and frontiers in SL research. The Web of Science Core Collection (WOSCC) was used to identify the 100 top-cited articles related to SL research.
Rong, Xu, Xin, Wu, Qiangqiang, Zhao, Qinglong, Yang   +3 more
openaire   +1 more source

WEE1 Inhibitor: Clinical Development [PDF]

Current Oncology Reports, 2021
Abstract Purpose of Review WEE1 inhibitor has been shown to potential chemotherapy or radiotherapy sensitivity in preclinical models, particularly in p53-mutated or deficient cancer cells although not exclusively. Here, we review the clinical development of WEE1 inhibitor in combination with chemotherapy or radiotherapy ...
Anthony Kong, Hisham Mehanna
exaly   +6 more sources