Results 141 to 150 of about 499,052 (176)

WEE1 stabilizes MYC to promote therapeutic resistance in esophageal adenocarcinoma. [PDF]

Cancer Lett
Thangaretnam K, Islam MO, Lv J, Zhang Z, Chen L, Ballout F, Lu H, Peng D, Zaika A, El-Rifai W, Giordano S, Ban Y, Bilbao D, Chen Z.   +13 more
europepmc   +1 more source

An overview of the DNA damage response in female reproductive system and breast cancers: A narrative review. [PDF]

Int J Reprod Biomed
Zafari M, Zarei H, Sadeghi E, Lotfi Asrami F, Bahmani F, Jahani S, Maliki DSK, Musavi H, Abdollahi A.   +8 more
europepmc   +1 more source

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma. [PDF]

MedComm (2020)
Huang J, Zhang Z, Xiao Y, Zhao Z, Luo Z, Liu J, Lai S, Song C, Feng S, Zhang S, Yu X, Tong Q, Zhang Y.   +12 more
europepmc   +1 more source

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Targeting WEE1 Kinase in Cancer

Trends in Pharmacological Sciences, 2016
WEE1 kinase plays a crucial role in the G2-M cell-cycle checkpoint arrest for DNA repair before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer cells often have a deficient G1-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is expressed at high levels in various cancer types including breast
Donald Backos, Philip Reigan, Christopher Matheson   +2 more
exaly   +3 more sources

WEE1 tyrosine kinase, a novel epigenetic modifier [PDF]

Trends in Genetics, 2013
The cell cycle requires cells to duplicate their chromatin, DNA, and histones, while retaining a subset of epigenetic marks, in a highly coordinated manner. The WEE1 kinase was identified as an important regulator during S phase, preventing entry into mitosis until DNA replication has been completed. Interestingly, WEE1 has also emerged as a key player
Kiran Mahajan, Nupam Mahajan
exaly   +3 more sources

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma [PDF]

Cancer Cell, 2010
SummaryKinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene expression profiles of various tumor types and reveal the wee1 kinase to be ...
P Wesseling, Gertjan Kaspers, Jacqueline Cloos   +2 more
exaly   +3 more sources

Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies

DNA Repair, 2021
Hematologic malignancies include various diseases that develop from hematopoietic stem cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based chemotherapy drugs are approved as standard therapeutic regimens for these malignancies.
Sajjad Vakili-Samiani, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Vahid Karpisheh, Pooya Jalali, Sara Adibfar, Majid Ahmadi, Abbas Ali Hosseinpour Feizi, Farhad Jadidi-Niaragh   +9 more
openaire   +2 more sources

Design, synthesis, and biological evaluation of Wee1 kinase degraders

European Journal of Medicinal Chemistry, 2022
Proteolysis targeting chimera (PROTAC) technology has received widespread attention in recent years as a promising strategy for drug development. Herein, we report a series of novel Wee1 degraders, which were designed and synthesized based on PROTAC technology by linking AZD1775 with CRBN ligands through linkers of different lengths and types.
Shulei, Zhu, Jieyu, Liu, Donghuai, Xiao, Peipei, Wang, Jingkun, Ma, Xiaobei, Hu, Jingfeng, Fu, Yubo, Zhou, Jia, Li, Wei, Lu   +9 more
openaire   +2 more sources

Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase

Nature, 1993
In most species, including the fission yeast Schizosaccharomyces pombe, the Cdc2/cyclin B mitosis-inducing kinase is maintained in an inhibited state during interphase as a result of phosphorylation of a tyrosine residue in the ATP-binding region of Cdc2 (refs 1-3).
Paul Russell
exaly   +3 more sources