Results 121 to 130 of about 57,794 (383)

Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA

PLoS ONE, 2023
Acute kidney injury (AKI) is a serious and frequently observed disease associated with high morbidity and mortality. Weighted gene co-expression network analysis (WGCNA) is a research method that converts the relationship between tens of thousands of ...
Jin-shuang Wei, Junlin Zhang, Junyu Wei, Miao-yue Hu, Xiuqi Chen, Xuankai Qin, Jie Chen, Feng-ying Lei, Yuanhan Qin   +8 more
semanticscholar   +1 more source

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

Profiling the accumulation of ten bioactive compounds in Rheum officinale across different growth years using integrated HPLC and transcriptomic approaches

Medicinal Plant Biology
Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia. Variations in the composition and accumulation of secondary metabolites in R. officinale have been observed to correlate with harvest periods. This study investigated
Yi-min Li, Xue-ru Wang, Ge Yang, Ting-ting Yan, Xiao-chen Hu, Liang Peng, Jing Gao, Feng Yan, Gang Zhang   +8 more
doaj   +1 more source

Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance

International Journal of General Medicine, 2021
Hua Ye,1 Mengxia Sun,2 Shiliang Huang,1 Feng Xu,1 Jian Wang,3 Huiwei Liu,1 Liangshun Zhang,1 Wenjing Luo,1 Wenying Guo,1 Zhe Wu,1 Jie Zhu,4 Hong Li4 1Department of Gastroenterology, Ningbo Medical Treatment Center Lihuili Hospital, Medical School of ...
Ye H, Sun M, Huang S, Xu F, Wang J, Liu H, Zhang L, Luo W, Guo W, Wu Z, Zhu J, Li H   +11 more
doaj  

Co-Expression Network Analysis Identifies Possible Hub Genes in Aging of the Human Prefrontal Cortex

Revista Ciencias de la Salud, 2019
Introduction: Aging is the main risk factor for the development of chronic diseases such as cancer, diabetes, Parkinson’s disease, and Alzheimer’s disease.
César Payán-Gómez, MD, MSc, PhD, Julián Riaño-Moreno, MD, MSc, Diana Amador-Muñoz, MD, MSc, Sandra Ramírez-Clavijo, MSc, PhD   +3 more
doaj   +1 more source

Stability Indicators in Network Reconstruction [PDF]

, 2012
The number of algorithms available to reconstruct a biological network from a dataset of high-throughput measurements is nowadays overwhelming, but evaluating their performance when the gold standard is unknown is a difficult task. Here we propose to use
Filosi, Michele, Furlanello, Cesare, Jurman, Giuseppe, Riccadonna, Samantha, Visintainer, Roberto   +4 more
core  

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. [PDF]

, 2016
BackgroundOur previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis model of multiple ...
Coppola, Giovanni, Gao, Fuying, Juknat, Ana, Kaushansky, Nathali, Kozela, Ewa, Vogel, Zvi   +5 more
core   +2 more sources

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Identification of biomarkers associated with ferroptosis in diabetic retinopathy based on WGCNA and machine learning

Frontiers in Genetics
Objective: Diabetic retinopathy (DR) is a chronic progressive eye disease that affects millions of diabetic patients worldwide, and ferroptosis may contribute to the underlying mechanisms of DR.
Hui Guo, Rong Xue, Guangming Wan
semanticscholar   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source