Results 121 to 130 of about 43,312 (289)

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Gene expression analysis and WGCNA.

, 2016
WGCNA analysis on EtOH-induced transcriptomic alterations in neural rosettes and NPC populations derived from hESCs compared to undifferentiated parental hESCs. A.
Yi Young Kim (3183111), Jin Seok Kim (459762), Michael Hoang (1481752), Nathan Mathiyakom (3183105), Ivan Roubal (3183102), Yong Kim (199695), Youn Soo Lee (3183108)   +6 more
core   +1 more source

Genome‐wide identification of the bZIP transcription factor family in sainfoin (Onobrychis viciifolia Scop.) and expression profiles in response to aluminum stress

Grassland Research, EarlyView.
Sainfoin is an important forage legume with potential for cultivation in stressful environments, but its molecular response to aluminum toxicity remains unclear. This study identified 236 basic leucine zipper (bZIP) transcription factor genes in sainfoin and analyzed their evolutionary features and regulatory potential.
Peng Li, Hao Wen, Yiwei Bai, Jiachen Liu, Hui Wang, Yunwei Zhang   +5 more
wiley   +1 more source

PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke-Induced COPD by Integrative Bioinformatics Analysis

International Journal of COPD, 2020
Qiang Zhang,1 Wei Song,1 Nahemuguli Ayidaerhan,2 Zheng He3 1Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110042, People’s Republic of China; 2Department of Pulmonary
Zhang Q, Song W, Ayidaerhan N, He Z
doaj  

Fuzzy Forests: Extending Random Forest Feature Selection for Correlated, High-Dimensional Data

Journal of Statistical Software, 2019
In this paper we introduce fuzzy forests, a novel machine learning algorithm for ranking the importance of features in high-dimensional classification and regression problems. Fuzzy forests is specifically designed to provide relatively unbiased rankings
Daniel Conn, Tuck Ngun, Gang Li, Christina M. Ramirez   +3 more
doaj   +1 more source

Weighted correlation network analysis (WGCNA) applied to the tomato fruit metabolome.

, 2011
BackgroundAdvances in "omics" technologies have revolutionized the collection of biological data. A matching revolution in our understanding of biological systems, however, will only be realized when similar advances are made in informatic analysis of ...
Meghan den Bakker, Matthew V DiLeo, Gary D Strahan, DiLeo Matthew V., Matthew V. DiLeo, Gary D. Strahan, Owen A Hoekenga, Hoekenga Owen A., Strahan Gary D., den Bakker Meghan, Owen A. Hoekenga   +10 more
core   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction

All Life
Cardiac fibroblasts (CFs) are of vital importance for post-myocardial infarction (MI) remodeling. This study explored the role of Placenta specific 8 (Plac8) in MI on the basis of single-cell RNA-Seq (scRNA-Seq) data (GSE136088) and micro-array data ...
Ting Fu, Jianping Gong, Lei Xu, Ningning Ji   +3 more
doaj   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Metabolic reprogramming and prognostic modeling in pancreatic cancer: insights from WGCNA

Frontiers in Genetics
PurposeMetabolic reprogramming plays a crucial role in multiple malignant features of pancreatic cancer (PC). However, few studies have comprehensively examined metabolic features of PC and provided guidance for their treatment.MethodsThis study tried to identify metabolism-associated hub genes based on metabolic phenotypic levels through weighted gene
Zhuo Song, Zhijia Sun, Yupeng Di, Xu Liu, Xiaoli Kang, Gang Ren, Yingjie Wang   +6 more
openaire   +3 more sources