Results 201 to 210 of about 45,444 (316)

CDKN2B Inhibits Vascular Smooth Muscle Phenotypic Switching in Corpus Spongiosum Surrounding the Urethral Plate in Hypospadias. [PDF]

Biomedicines
Huang J, Xu Z, Huang J, Yin X, Huang Y, Chen F.   +5 more
europepmc   +1 more source

CWGCNA: an R package to perform causal inference from the WGCNA framework

NAR Genomics and Bioinformatics
Abstract WGCNA (weighted gene co-expression network analysis) is a very useful tool for identifying co-expressed gene modules and detecting their correlations to phenotypic traits. Here, we explored more possibilities about it and developed the R package CWGCNA (causal WGCNA), which works from the traditional WGCNA pipeline but mines ...
openaire   +2 more sources

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Murine Model Insights: Identifying Dusp15 as a Novel Biomarker for Diabetic Cardiomyopathy Uncovered Through Integrated Omics Analysis and Experimental Validation

Diabetes, Metabolic Syndrome and Obesity
Lingling Zhu,1,* Ya Dong,2,* Hang Guo,1 Jie Qiu,1 Jun Guo,1 Yonghui Hu,3 Congqing Pan1 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of ...
Zhu L, Dong Y, Guo H, Qiu J, Guo J, Hu Y, Pan C   +6 more
doaj  

WGCNA and Machine Learning-Based Integrative Bioinformatics Analysis for Identifying Key Genes of Colorectal Cancer

Md. Al Mehedi Hasan, Md. Maniruzzaman, Jungpil Shin   +2 more
openalex   +1 more source

Elevational variation in heart mass and suppression of hypoxia‐induced right ventricle hypertrophy in Andean leaf‐eared mice (Phyllotis)

The Journal of Physiology, EarlyView.
Abstract figure legend In lowland mammals that ascend to high elevation, hypoxia‐induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right‐ventricle (RV) hypertrophy. Andean mice with broad elevational ranges have greater heart mass relative to body size at higher elevations, but they ...
Naim M. Bautista, Nathanael D. Herrera, Marcial Quiroga‐Carmona, Chandrasekhar Natarajan, Adriana Rico‐Cernohorska, Jorge Salazar Bravo, Graham R. Scott, Guillermo D'Elía, Zachary A. Cheviron, Jay F. Storz   +9 more
wiley   +1 more source

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity. [PDF]

Commun Med (Lond)
Rider A, Grantham HJ, Smith GR, Watson DS, Casement J, Cockell SJ, Gisby J, Foulkes AC, Henkin R, Iqbal WA, Ewen T, Amarnath S, Ng S, Zuliani P, Dand N, Stocken D, Traini C, Thomas E, Kalyana-Sundaram S, Rajpal DK, Smith KM, Barker JN, Griffiths CEM, Di Meglio P, Smith CH, Warren RB, Barnes MR, Reynolds NJ, PSORT consortium.   +28 more
europepmc   +1 more source

Identifying Core Genes Related to Low-Temperature Stress Resistance in Quinoa Seedlings Based on WGCNA [PDF]

Lingyuan Zhang, Guofei Jiang, Xuqin Wang, Yutao Bai, Ping Zhang, Junna Liu, Li Li, Liubin Huang, Peng Qin   +8 more
openalex   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology
Zuochao Yao, Lu Lu, Qianhui Xu, Shan Hua, Hui Wang, Hua Jiang Department of Plastic and Reconstructive Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of ChinaCorrespondence: Hui Wang; Hua Jiang,
Yao Z, Lu L, Xu Q, Hua S, Wang H, Jiang H   +5 more
doaj