Results 41 to 50 of about 5,237 (144)

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Restricted Myogenic Potential of Mesenchymal Stromal Cells Isolated from Umbilical Cord

Cell Transplantation, 2012
Nonhematopoietic cord blood cells and mesenchymal cells of umbilical cord Wharton's jelly have been shown to be able to differentiate into various cell types.
Iwona Grabowska, Edyta Brzoska, Agnieszka Gawrysiak, Wladyslawa Streminska, Jerzy Moraczewski, Zbigniew Polanski, Grazyna Hoser, Jerzy Kawiak, Eugeniusz K. Machaj, Zygmunt Pojda, Maria A. Ciemerych   +10 more
doaj   +1 more source

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Characterization of mesenchymal stem cells isolated from Wharton’s jelly of the human umbilical cord

Egyptian Liver Journal, 2022
Background Isolation of post-partum umbilical cord Wharton’s jelly stem cells has gained attention as an alternative source of the bone marrow. Because easy isolation, lack of ethical concerns, and the presence of both embryonic and adult stem cells have
Hager Abouelnaga, Doaa El-Khateeb, Yasmine Moemen, Ashraf El-Fert, Mohamed Elgazzar, Ashraf Khalil   +5 more
doaj   +1 more source

Kartogenin releasing decellularized umbilical cord Wharton's jelly scaffold promotes rotator cuff fibrocartilaginous interface regeneration

Materials & Design, 2022
Fibrocartilaginous regeneration at the tendon-to-bone interface is a major challenge for rotator cuff tear repair. We fabricated a decellularized umbilical cord Wharton’s jelly (DUCWJ) scaffold by decellularization method and performed histological and ...
Zhiguo Yuan, Hao Li, Songlin He, Cangjian Gao, Zhen Yang, Weiwei Xin, Ruixin Lin, Quanyi Guo, You Wang   +8 more
doaj   +1 more source

Structural and Mechanical Characterization of Directionally Frozen Cellulose Scaffolds for Cultivated Meat Applications

Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.
Bamboo‐derived cellulose suspensions were processed by high‐pressure homogenization and fabricated into porous scaffolds by directional freezing followed by freeze‐drying. Rheological characterization preceded scaffold fabrication, followed by mechanical testing and cell seeding evaluation.
Yarden Munish, Vlad Shumeiko, Shadi Tawil, Yael Gilad, Joseph Kippen, Alon Gershkoviz, Ido Braslavsky, Sharon Schlesinger, Oded Shoseyov   +8 more
wiley   +1 more source

Treatment of Knee Osteoarthritis and Chondral Injury with Umbilical Cord/Wharton’s Jelly-Derived Mesenchymal Stem Cells: A Systematic Review of Safety and Efficacy

Journal of Functional Biomaterials
Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide, with no current treatment modality able to prevent the progressive destruction of articular cartilage.
Mohd Ishak-Samrin, Isa Naina-Mohamed, Mohamed S. Zulfarina, S. Fadilah Abdul Wahid, Ahmad Farihan Mohd Don, Norlelawati Mohamad, Muhamad Karbela Reza Ramlan, Akmal Hisham Md Yusoff Badrul   +7 more
doaj   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2884-2894, August 2026.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source