Results 41 to 50 of about 5,219 (144)

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Restricted Myogenic Potential of Mesenchymal Stromal Cells Isolated from Umbilical Cord

Cell Transplantation, 2012
Nonhematopoietic cord blood cells and mesenchymal cells of umbilical cord Wharton's jelly have been shown to be able to differentiate into various cell types.
Iwona Grabowska, Edyta Brzoska, Agnieszka Gawrysiak, Wladyslawa Streminska, Jerzy Moraczewski, Zbigniew Polanski, Grazyna Hoser, Jerzy Kawiak, Eugeniusz K. Machaj, Zygmunt Pojda, Maria A. Ciemerych   +10 more
doaj   +1 more source

Characterization of mesenchymal stem cells isolated from Wharton’s jelly of the human umbilical cord

Egyptian Liver Journal, 2022
Background Isolation of post-partum umbilical cord Wharton’s jelly stem cells has gained attention as an alternative source of the bone marrow. Because easy isolation, lack of ethical concerns, and the presence of both embryonic and adult stem cells have
Hager Abouelnaga, Doaa El-Khateeb, Yasmine Moemen, Ashraf El-Fert, Mohamed Elgazzar, Ashraf Khalil   +5 more
doaj   +1 more source

Kartogenin releasing decellularized umbilical cord Wharton's jelly scaffold promotes rotator cuff fibrocartilaginous interface regeneration

Materials & Design, 2022
Fibrocartilaginous regeneration at the tendon-to-bone interface is a major challenge for rotator cuff tear repair. We fabricated a decellularized umbilical cord Wharton’s jelly (DUCWJ) scaffold by decellularization method and performed histological and ...
Zhiguo Yuan, Hao Li, Songlin He, Cangjian Gao, Zhen Yang, Weiwei Xin, Ruixin Lin, Quanyi Guo, You Wang   +8 more
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Treatment of Knee Osteoarthritis and Chondral Injury with Umbilical Cord/Wharton’s Jelly-Derived Mesenchymal Stem Cells: A Systematic Review of Safety and Efficacy

Journal of Functional Biomaterials
Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide, with no current treatment modality able to prevent the progressive destruction of articular cartilage.
Mohd Ishak-Samrin, Isa Naina-Mohamed, Mohamed S. Zulfarina, S. Fadilah Abdul Wahid, Ahmad Farihan Mohd Don, Norlelawati Mohamad, Muhamad Karbela Reza Ramlan, Akmal Hisham Md Yusoff Badrul   +7 more
doaj   +1 more source

Integrating Nuclear Magnetic Resonance into Bioprocess Control of Clinical‐Grade Extracellular Vesicle Manufacturing

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Nuclear magnetic resonance (NMR) in bioprocess design for the production of extracellular vesicles (EVs). NMR‐metabolomics enables real‐time bioprocess intelligence, bridging biological complexity with GMP rigor and accelerating the clinical translation of EV‐based therapies.
Santiago Roura, Núria Amigó, Joaquim Vives   +2 more
wiley   +1 more source

Umbilical cord Wharton's jelly repeated culture system: a new device and method for obtaining abundant mesenchymal stem cells for bone tissue engineering. [PDF]

PLoS ONE, 2014
To date, various types of cells for seeding regenerative scaffolds have been used for bone tissue engineering. Among seed cells, the mesenchymal stem cells derived from human umbilical cord Wharton's jelly (hUCMSCs) represent a promising candidate and ...
Zhengqi Chang, Tianyong Hou, Junchao Xing, Xuehui Wu, Huiyong Jin, Zhiqiang Li, Moyuan Deng, Zhao Xie, Jianzhong Xu   +8 more
doaj   +1 more source

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu, Usri H. Ibrahim, Irene Mackraj, Carola Niesler   +3 more
wiley   +1 more source