Results 141 to 150 of about 131,653 (265)

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Cortical Thickness and Appetite Hormones in Adolescent Obesity and Binge Eating Disorder: A Comparative Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined cortical thickness and appetite‐regulating hormones—neuropeptide Y (NPY) and ghrelin—to better understand the neurobiological mechanisms underlying binge eating disorder (BED) and obesity in adolescence. We compared adolescents with BED and obesity, adolescents with obesity without BED, and healthy controls (HCs),
Serkan Turan, İbrahim Mert Erbaş, Fatma Ceren Sarıoğlu, Berrin Çavuşoğlu, Ezgi Molla, Ali Rıza Şişman, Sevay Alsen Güney, Handan Güleryüz, Ayhan Abacı, Yeşim Öztürk, Aynur Pekcanlar Akay   +10 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Comparative anatomy and metabolic profiles of brown and white adipose tissue in humans. [PDF]

Front Endocrinol (Lausanne)
Villarreal J, Baranova A.
europepmc   +1 more source

Proso Millet (Panicum miliaceum): Nutritional Composition, Functional Attributes, and Health Implications

Future Postharvest and Food, EarlyView.
A nutrient‐dense grain, proso millet is well‐known for its high protein content and vital amino acids. It is high in fiber, vitamins, and minerals and has many health advantages, including promoting heart health, enhancing digestion, and helping with weight management.
Sangeeta Yadav, Pratiksha Singh, Mazia Ahmed, Pinki Saini   +3 more
wiley   +1 more source

C/EBP α is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice. [PDF]

Obesity (Silver Spring)
Hu KY, Ma YL, Dodge EA, Maguire OAB, Matias CV, Barney RP, Himede HS, Pardo JG, Cepeda M, Gordon SM, Bauer RC.   +10 more
europepmc   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

White Adipose Tissue as a Functional Target of Secondary Bile Acids in Rainbow Trout (Oncorhynchus mykiss). [PDF]

Mar Biotechnol (NY)
Pérez-Tierra G, Calo J, Blanco AM, Soengas JL.   +3 more
europepmc   +1 more source

Semaphorin 7A regulates axon outgrowth in subcutaneous white adipose tissue. [PDF]

Mol Metab
Willows JW, Lazor LM, Wandling G, Butke W, Fenesha F, Corps KN, Peters SB, Townsend KL.   +7 more
europepmc   +1 more source

MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion. [PDF]

J Exp Med
Wetterwald L, Köck A, Wyss T, Arroz-Madeira S, Prat-Luri B, Jaquet M, Petit B, Vozenin MC, Ylä-Herttuala S, Dutoit V, Migliorini D, Schaeuble K, Brisken C, Delorenzi M, Sabine A, Petrova TV.   +15 more
europepmc   +1 more source