Results 161 to 170 of about 128,051 (312)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

The Anti-Obesity Effect of Fish Oil in Diet-Induced Obese Mice Occurs via Both Decreased Food Intake and the Induction of Heat Production Genes in Brown but Not White Adipose Tissue [PDF]

Takahiko Obo, Hiroshi Hashiguchi, Eriko Matsuda, Shigeru Kawade, Kazuma Ogiso, Haruki Iwai, Koji Ataka, Osamu Yasuda, Aiko Arimura, Takahisa Deguchi, Katsutaro Morino, Akihiro Asakawa, Yoshihiko Nishio   +12 more
openalex   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells [PDF]

, 2012
Khanh‐Van Tran, Olga Gealekman, Andrea Frontini, Maria Cristina Zingaretti, Manrico Morroni, Antonio Giordano, Arianna Smorlesi, Jessica Perugini, Rita De Matteis, Andrea Sbarbati, Silvia Corvera, Saverio Cinti   +11 more
openalex   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue. [PDF]

Cell Commun Signal
Peng XM, He R, Wang HY, Liu JD, Xie YY, Wang ZH, Deng HY, Wang WS, Zhu ZZ, Ge J, Liu YL, Gao RH, Yang M, Li DP, Kang QQ, Pan RP, Chen Y.   +16 more
europepmc   +1 more source

The gut microbiota modulates the white adipose tissue functional remodeling

, 2018
Nicolas Suarez Zamorano
openalex   +1 more source

Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue [PDF]

, 2010
Siva S. V. P. Sakamuri, Shanmugam S Jeya Kumar, Putcha Uday Kumar, S.S.Y.H. Qadri, Ayyalasomayajula Vajreswari   +4 more
openalex   +1 more source