Results 41 to 50 of about 116,442 (217)

Brown adipose tissue [PDF]

, 2012
Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure,
Townsend, Kristy L, Tseng, Yu-Hua
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Adipose extracellular matrix remodelling in obesity and insulin resistance [PDF]

, 2016
The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow adipocytes and their precursor cells to change cell shape and function in adaptation to nutritional cues.
Agnihotri, Aouadi, Arany, Aumailley, Bauters, Berger, Bertola, Bonnans, Bonner, Bourlier, Brahimi-Horn, Brakenhielm, Brew, Cao, Chapman, Chavey, Chinsomboon, Choi, Chun, Chun, Chun, Daviet, De Lin, Derosa, Desgrosellier, Divoux, Facchini, Febbraio, Feral, Filippov, Fraser, Gerin, Ghosh, Hajri, Halberg, Hames, Han, Haslam, Heni, Hopps, Huber, Hynes, Inoue, Jaworski, Ji, Jiang, Kahles, Kandalam, Kang, Kang, Kang, Kang, Khan, Kiefer, Kiefer, Kleiner, Kodama, Kulkarni, Lancha, Lawler, Lee, Leick, Li, Li Kang, Lijnen, Lijnen, Liu, Liu, Lu, Luk, Lumeng, Maquoi, Maquoi, Mariman, Martinez-Santibanez, Matsuo, Meakin, Menghini, Menghini, Miller, Moore, Murphy, Nagase, Naor, Nasser, Nergiz-Unal, Nicholls, Nomiyama, Oh, Ponta, Rong, Rowe, Rupnick, Sato, Signorelli, Spencer, Stern, Strissel, Sun, Sun, Sun, Sun, Sung, Szabova, Tae-Hwa Chun, Takahashi, Thomas, Thrailkill, Tinahones, Tracy, Traurig, Van Hul, Van Hul, Van Hul, Van Hul, Varma, Weis, Wentworth, Williams, Wu, Yang, Yeh, Zheng, Zoller, Zong   +124 more
core   +2 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Insulin degradation by adipose tissue is increased in human obesity

, 1995
White adipose tissue samples from obese and lean patients were used for the estimation ofinsulin protease and insulin:glutathione transhydrogenase using 1251-labeled insulin.
Alemany, Marià, 1946-, Fernández López, José Antonio, Formiguera Sala, X., Foz Sala, M. (Màrius), Rafecas Jorba, Immaculada, Remesar Betlloch, Xavier, Salinas, Isabel   +6 more
core   +2 more sources

Polyunsaturated fatty acids stimulate de novo lipogenesis and improve glucose homeostasis during refeeding with high fat diet [PDF]

, 2017
The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia—which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated ...
Bianco, Francesca, Cancelliere, Rosa, Crescenzo, Raffaella, Dulloo, Abdul G., Giacco, Antonia, Iossa, Susanna, Liverini, Giovanna, Mazzoli, Arianna   +7 more
core   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

HOXC10 suppresses browning of white adipose tissues [PDF]

Experimental & Molecular Medicine, 2017
Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor ...
Hwee Yim Angeline Tan, Lei Sun, Lei Sun, Wanjin Hong, Yvonne Ng, Weiping Han, Sin Yee Gun, Sook Yoong Chia, Shi-Xiong Tan, Shi-Xiong Tan   +9 more
openaire   +2 more sources

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice [PDF]

, 2016
The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice.
Hankir, Mohammed [u.v.m.], Klöting, Nora, Kranz, Mathias, Kunath, Anne, Köhrle, Josef, Rijntjes, Eddy, Steinhoff, Karen, Weiner, Juliane, Zeisig, Vilia   +8 more
core   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source