Results 51 to 60 of about 240,259 (361)

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Nature Communications, 2023
Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human ...
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono Nankam, Scott Frendo-Cumbo, Jesper Bäckdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. Blaak, Patrik L. Ståhl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blüher, Mikael Rydén, Niklas Mejhert   +27 more
doaj   +1 more source

Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs [PDF]

, 1993
Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous ...
Arthur, John R., Duncan, Jacqueline S., Nicol, Fergus, Thomas, Moira E.A., Trayhurn, Paul   +4 more
core   +1 more source

White adipose tissue as a target for cadmium toxicity

Frontiers in Pharmacology, 2022
Cadmium (Cd) is a widespread heavy metal known as a toxic environmental pollutant. Cd exposure is threatening due to its bioaccumulation trait in living systems that exceeds 35 years without a beneficial biological role. Acute exposure to high Cd doses was reported to impact adipose tissue (AT) function adversely.
Sarra Mohammed Attia, Sarra Mohammed Attia, Sandra Concepcion Das, Sandra Concepcion Das, Kavitha Varadharajan, Hamda A. Al-Naemi, Hamda A. Al-Naemi   +6 more
openaire   +3 more sources

FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study [PDF]

, 2018
Aims/hypothesis: By genome-wide association meta-analysis, 17 genetic loci associated with fasting serum insulin (FSI), a marker of systemic insulin resistance, have been identified. To define potential culprit genes in these loci, in a cross-sectional
Arner, Peter, Dahlman, Ingrid, Kulyte, Agne, Lundbäck, Veroniqa, Marcus, Claude, Ryden, Mikael, Strawbridge, Rona J.   +6 more
core   +1 more source

Adipose tissue: colors, depots and functions

Ожирение и метаболизм, 2021
Obesity is a chronic disease characterized by excessive accumulation of adipose tissue. The prevalence of obesity and associated diseases has prompted researchers to expand the study of the biology of adipose tissue.
T. I. Romantsova
doaj   +1 more source

Adipose extracellular matrix remodelling in obesity and insulin resistance [PDF]

, 2016
The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow adipocytes and their precursor cells to change cell shape and function in adaptation to nutritional cues.
Agnihotri, Aouadi, Arany, Aumailley, Bauters, Berger, Bertola, Bonnans, Bonner, Bourlier, Brahimi-Horn, Brakenhielm, Brew, Cao, Chapman, Chavey, Chinsomboon, Choi, Chun, Chun, Chun, Daviet, De Lin, Derosa, Desgrosellier, Divoux, Facchini, Febbraio, Feral, Filippov, Fraser, Gerin, Ghosh, Hajri, Halberg, Hames, Han, Haslam, Heni, Hopps, Huber, Hynes, Inoue, Jaworski, Ji, Jiang, Kahles, Kandalam, Kang, Kang, Kang, Kang, Khan, Kiefer, Kiefer, Kleiner, Kodama, Kulkarni, Lancha, Lawler, Lee, Leick, Li, Li Kang, Lijnen, Lijnen, Liu, Liu, Lu, Luk, Lumeng, Maquoi, Maquoi, Mariman, Martinez-Santibanez, Matsuo, Meakin, Menghini, Menghini, Miller, Moore, Murphy, Nagase, Naor, Nasser, Nergiz-Unal, Nicholls, Nomiyama, Oh, Ponta, Rong, Rowe, Rupnick, Sato, Signorelli, Spencer, Stern, Strissel, Sun, Sun, Sun, Sun, Sung, Szabova, Tae-Hwa Chun, Takahashi, Thomas, Thrailkill, Tinahones, Tracy, Traurig, Van Hul, Van Hul, Van Hul, Van Hul, Varma, Weis, Wentworth, Williams, Wu, Yang, Yeh, Zheng, Zoller, Zong   +124 more
core   +2 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice [PDF]

, 2016
The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice.
Hankir, Mohammed [u.v.m.], Klöting, Nora, Kranz, Mathias, Kunath, Anne, Köhrle, Josef, Rijntjes, Eddy, Steinhoff, Karen, Weiner, Juliane, Zeisig, Vilia   +8 more
core   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Experimental and Molecular Medicine, 2023
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam   +10 more
doaj   +1 more source