Results 51 to 60 of about 253,274 (360)

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ [PDF]

Proceedings of the Nutrition Society, 2001
The traditional role attributed to white adipose tissue is energy storage, fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role in inflammatory processes has been proposed. A radical change in perspective followed the discovery
P, Trayhurn, J H, Beattie
openaire   +2 more sources

Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver [PDF]

, 2013
Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in
A Karamitri, A Shore, A Unami, AL Vallerand, Andrew M. Shore, Angeliki Karamitri, AV Gabova, B Cannon, B Cannon, BM Spiegelman, DW Gong, G Karamanlidis, H Ohguchi, J Liu, J Moitra, JE Silva, JK Kim, John R. Speakman, JR Hall, K Kajimoto, M Solter, M Watanabe, M Watanabe, M Watanabe, MA Thorne, Marc Lenburg, ME Symonds, Michael A. Lomax, N Yamazaki, Neil S. Graham, O Gavrilova, O Gavrilova, O Gavrilova, OA Gavrilova, Paul Kemp, PE Penner, R Edgar, S Bi, S Yu, T Daikoku, T Yamamoto, TB Walden   +41 more
core   +8 more sources

Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]

, 2007
*Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky, AA Ptitsyn, AA Ptitsyn, Andrey A Ptitsyn, AU Viola, BP Tu, E Selkov, E Selkov, H Yang, HR Ueda, JB Hogenesch, Jeffrey M Gimble, KF Storch, PJ Enriori, RR Klevecz, S Panda, S Zvonic, SN Archer   +17 more
core   +3 more sources

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +1 more source

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]

, 2017
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E, Chen, Tzu-Chieh, Kuo, Taiyi, Lee, Rebecca A, Nguyen, Nguyen Huynh Thao, Wang, Jen-Chywan, Zhang, Danyun   +6 more
core   +1 more source

Circadian control of white and brown adipose tissues

Current Opinion in Genetics & Development, 2023
White and brown adipose tissues are highly dynamic organs anticipating and responding to changes in the environment. The circadian timing system facilitates anticipation, and it is therefore not surprising that circadian disturbances, a prominent feature of modern 24/7 society, increase the risk for (cardio)metabolic diseases.
Yue, K.M., Rensen, P.C.N., Kooijman, S.
openaire   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Experimental and Molecular Medicine, 2023
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam   +10 more
doaj   +1 more source

Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health [PDF]

, 2016
Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the role of this metabolically active tissue in whole-
Andrade, Cl��udia Marlise Balbinotti, Boguszewski, Cesar, Carrillo, Andres E, Flouris, Andreas D, Jamurtas, Athanasios Z, Kawashita, Nair Honda, Koutedakis, Yiannis, Metsios, George S, Nadolnik, Liliya, Sakellariou, Paraskevi, Svensson, Per-Arne, Valente, Angelica   +11 more
core   +1 more source