Results 61 to 70 of about 253,274 (360)

Metabolic remodeling of white adipose tissue in obesity [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2014
Adipose tissue metabolism is a critical regulator of adiposity and whole body energy expenditure; however, metabolic changes that occur in white adipose tissue (WAT) with obesity remain unclear. The purpose of this study was to understand the metabolic and bioenergetic changes occurring in WAT with obesity.
Timothy D, Cummins, Candice R, Holden, Brian E, Sansbury, Andrew A, Gibb, Jasmit, Shah, Nagma, Zafar, Yunan, Tang, Jason, Hellmann, Shesh N, Rai, Matthew, Spite, Aruni, Bhatnagar, Bradford G, Hill   +11 more
openaire   +2 more sources

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism

Redox Biology, 2017
Adipose tissue is a complex and multi-faceted organ. It responds dynamically to internal and external stimuli, depending on the developmental stage and activity of the organism.
Teresa G. Valencak, Anne Osterrieder, Tim J. Schulz   +2 more
doaj   +1 more source

Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice [PDF]

, 2017
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population.
Adams, Alan C Perkins, Andrew C Adams, Belov, Betz, Blondin, Cannon, Degirolamo, Dennis P Smith, Foltz, Fon Tacer, Francis J. P Ebling, Frayn, Hotamisligil, James D Dunbar, Jeni C Luckett, Jo E Lewis, Kharitonenkov, Kostas Tsintzas, Mottillo, Ouellet, Park, Paul J Emmerson, Peirce, Ricardo J Samms, Rondinone, Samms, Samms, Scott Cooper, Stanford, Suh, Sun, Tilman, Tsintzas, Wu   +34 more
core   +1 more source

Metabolic control by AMPK in white adipose tissue

Trends in Endocrinology & Metabolism, 2023
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new ...
Olga Göransson, Franziska Kopietz, Mark H. Rider   +2 more
openaire   +3 more sources

Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters

Arthritis Care &Research, EarlyView.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US‐based skin assessments for their face validity (differentiation between involved SSc and healthy
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Nature Communications, 2023
Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human ...
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono Nankam, Scott Frendo-Cumbo, Jesper Bäckdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. Blaak, Patrik L. Ståhl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blüher, Mikael Rydén, Niklas Mejhert   +27 more
doaj   +1 more source

Adipose tissue: colors, depots and functions

Ожирение и метаболизм, 2021
Obesity is a chronic disease characterized by excessive accumulation of adipose tissue. The prevalence of obesity and associated diseases has prompted researchers to expand the study of the biology of adipose tissue.
T. I. Romantsova
doaj   +1 more source

Metabolic effects of FGF-21: thermoregulation and beyond [PDF]

, 2015
Fibroblast growth factor (FGF)-21, a member of the FGF family, is a novel hormone involved in the control of metabolism by modulating glucose homeostasis, insulin sensitivity, ketogenesis, and promoting adipose tissue “browning.” Recent studies ...
Celi, Francesco S., Farrar, Jared S., Ni, Bin, Vaitkus, Janina A.   +3 more
core   +3 more sources

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source