Results 51 to 60 of about 4,320,312 (250)

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation

, 2015
Conversion of white into brown adipose tissue may have important implications in obesity resistance and treatment. Several browning agents or conditions ignite thermogenesis in white adipose tissue (WAT).
Golic, Igor, Korać, Bato, Korac, Aleksandra, Markelic, Milica, Stančić, Ana, Janković, Aleksandra, Otašević, Vesna, Buzadžić, Biljana J., Buzadzic, Biljana, Korać, Bato M.   +9 more
core   +1 more source

Chronic cold exposure: A white adipose tissue browning factor [PDF]

, 2015
In the human body, there are two major subtypes of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT). Using 18F-fluorodeoxyglucose (FDG), an intravenously administered radioactive glucose analog, it was demonstrated with positron ...
Ghenev, Peter; Medical University of Varna, Kitanova, Martina; Medical University of Varna   +1 more
core   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway [PDF]

, 2014
Inorganic nitrate was once considered an oxidation end-product of nitric oxide metabolism with little biological activity. However, recent studies have demonstrated that dietary nitrate can modulate mitochondrial function in man and is effective in ...
Fernandez, BO, Murfitt, Steven A, Ashmore, T., Murray, Andrew J, Kotwica, A.O., Feelisch, M., Feelisch, M, Murfitt, SA, Griffin, JL, Murray, AJ, Fernandez, Bernadette O, Feelisch, Martin, Ashmore, T, Kotwica, AO, Roberts, Lee D, Fernandez, B.O., Murfitt, S.A., Kotwica, Aleksandra O, Griffin, J.L., Murray, A.J., Roberts, LD, Griffin, Julian L, Ashmore, Tom, Roberts, L.D.   +23 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Epigenetic Regulators of White Adipocyte Browning

Epigenomes, 2021
Adipocytes play an essential role in maintaining energy homeostasis in mammals. The primary function of white adipose tissue (WAT) is to store energy; for brown adipose tissue (BAT), primary function is to release fats in the form of heat.
Ravikanth Nanduri
doaj   +1 more source

Blood Vessels in White and Brown Adipose Tissues

, 2013
The adipose tissue is composed of two major subtypes, white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT mainly stores excess energy in, BAT plays a role in burning energy and generating heat in a process known as non-shivering ...
Honek, J, Lim, S, Sharon Lim, Yihai Cao, Cao, Y, Jennifer Honek   +5 more
core   +1 more source