Results 51 to 60 of about 4,186,199 (340)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Design and Validation of Diffusion MRI Models of White Matter

Frontiers of Physics, 2017
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules is conveniently on a length scale similar to that of the ...
Ileana O. Jelescu, M. Budde
semanticscholar   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

The Robustness of White Matter Brain Networks Decreases with Aging

Journal of Integrative Neuroscience
Background: White matter (WM) is a principal component of the human brain, forming the structural basis for neural transmission between cortico-cortical and subcortical structures.
Chenye Huang, Xie Wang, Daojun Xie
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Compression analysis of the gray and white matter of the spinal cord

Neural Regeneration Research, 2020
The spinal cord is composed of gray matter and white matter. It is well known that the properties of these two tissues differ considerably. Spinal diseases often present with symptoms that are caused by spinal cord compression.
Norihiro Nishida, Fei Jiang, Junji Ohgi, Akihiro Tanaka, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Takashi Sakai, Itsuo Sakuramoto, Xian Chen   +9 more
doaj   +1 more source

Tract Specific White Matter Lesion Load Affects White Matter Microstructure and Their Relationships With Functional Connectivity and Cognitive Decline

Frontiers in Aging Neuroscience, 2022
White matter hyperintensities (WMHs) are associated with cognitive decline. Assessing the effect of WMH on WM microstructural changes and its relationships with structural and functional connectivity to multiple cognitive domains are helpful to better ...
Tae Kim, Tae Kim, Howard J. Aizenstein, Beth E. Snitz, Yu Cheng, Yue-Fang Chang, Rebecca E. Roush, Theodore J. Huppert, Theodore J. Huppert, Annie Cohen, Jack Doman, James T. Becker   +11 more
doaj   +1 more source

White matter hyperintensities and imaging patterns of brain ageing in the general population.

Brain : a journal of neurology, 2016
White matter hyperintensities are associated with increased risk of dementia and cognitive decline. The current study investigates the relationship between white matter hyperintensities burden and patterns of brain atrophy associated with brain ageing ...
M. Habes, G. Erus, J. Toledo, Tianhao Zhang, N. Bryan, L. Launer, Y. Rosseel, Deborah Janowitz, J. Doshi, S. Van der Auwera, Bettina von Sarnowski, K. Hegenscheid, N. Hosten, G. Homuth, H. Völzke, U. Schminke, W. Hoffmann, H. Grabe, C. Davatzikos   +18 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

White Matter Hyperintensities: Cerebral Small‐Vessel Diseases and White Matter Microstructural Impairments

iRADIOLOGY
White matter hyperintensities (WMH) are very widespread in older adults and are imaging features of both cerebral small‐vessel disease and white matter microstructural impairments. Recent studies have demonstrated a close association between WMH and some
Hui Huang, Wei Song, Pengyu Wang, Ye Zhu, Lei Zheng, Chenzhen Shen, Hui Xu, Jianfeng Qiu   +7 more
doaj   +1 more source