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Whitehead on perishing [PDF]

open access: yesFilozofija i Društvo, 2023
This article deals with the problem of cessation in Whitehead’s philosophy. By focusing on his Process and Reality, but also on his other works, different temporal, mereological and other aspects of perishing are analyzed, with special attention
Losoncz Mark
doaj   +3 more sources

A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals

open access: yesBMC Biology, 2022
Background The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a short pseudoautosomal region. While
Jennifer F. Hughes   +7 more
doaj   +1 more source

GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque

open access: yesG3: Genes, Genomes, Genetics, 2021
Gene conversion is GC-biased across a wide range of taxa. Large palindromes on mammalian sex chromosomes undergo frequent gene conversion that maintains arm-to-arm sequence identity greater than 99%, which may increase their susceptibility to the effects
Emily K Jackson   +3 more
doaj   +1 more source

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

open access: yesNature Communications, 2022
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Alessandra Dall’Agnese   +19 more
doaj   +1 more source

On the New and the Novel: An Adventure in the Temporal Logics

open access: yesEidos. A Journal for Philosophy of Culture, 2021
This paper is an adventure of ideas. More specifically, it is a continuation of the adventure of ideas concerning the relations between creativity and logic at the level of being one finds in the work of Whitehead and his interpreters/inheritors.
Matthew Z. Donnelly
doaj   +1 more source

Georg Northoff's Neurophilosophical Approach

open access: yesRUDN Journal of Philosophy, 2022
When trying to give a universal definition to the term “neurophilosophy,” difficulties arise, since each researcher who identifies himself as a member of this field sets his own definition.
Anastasiia A. Zhudina
doaj   +1 more source

Fate specification is spatially intermingled across planarian stem cells

open access: yesNature Communications, 2023
Regeneration requires mechanisms for producing a wide array of cell types. Neoblasts are stem cells in the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types.
Chanyoung Park   +3 more
doaj   +1 more source

The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

open access: yesNature Communications, 2020
Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a ...
Colin Y. Kim   +5 more
doaj   +1 more source

On Fox spaces and Jacobi identities [PDF]

open access: yes, 2007
In 1945, R. Fox introduced the so-called Fox torus homotopy groups in which the usual homotopy groups are embedded and their Whitehead products are expressed as commutators.
Golasinski, Marek   +2 more
core   +3 more sources

Quantitative Analysis of Cellular Diacylglycerol Content

open access: yesBio-Protocol, 2014
Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse   +2 more
doaj   +1 more source

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