Results 31 to 40 of about 83,088 (307)

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

open access: yesNature Communications, 2023
Plant biosynthetic enzymes rapidly evolve to catalyze specialized reactions. Here, the authors present the crystal structure and mechanism of COSY, the enzyme involved in coumarin biosynthesis of the BAHD-acyltransferase family that catalyzes an ...
Colin Y. Kim   +7 more
doaj   +1 more source

Numerical Method for Fractional Model of Newell-Whitehead-Segel Equation

open access: yesFrontiers of Physics, 2019
The aim of the present work is to devote a friendly approach based on Adomian decoposition method (ADM) to find the numerical solution of the time-fractional Newell-Whitehead-Segel equation.
A. Prakash, Vijay Verma
semanticscholar   +1 more source

Analysis and Examination of the Influence of Whitehead's Process Philosophy on Theological Transformation, Focusing on the Issue of "Becoming" [PDF]

open access: yesJournal of Philosophical Investigations
Alfred North Whitehead's "process philosophy," a novel and influential perspective in contemporary philosophy, examines the organic and interconnected relationships between the various elements of existence and processes.
Mahdi Monazzah   +2 more
doaj   +1 more source

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

open access: yesCell Reports, 2020
Summary: The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a role promoting the evolution of new heritable traits.
Peter Tsvetkov   +8 more
doaj   +1 more source

Fusarium Crown Rot Whitehead Symptom as Influenced by Wheat Crop Management and Sampling Date.

open access: yesPlant Disease, 2019
Symptoms of Fusarium crown rot of wheat include premature death of inflorescens (whiteheads), lesions on subcrown internodes, and rotting of crown tissue and lower stem internodes.
R. Smiley
semanticscholar   +1 more source

Spanier–Whitehead K-duality for C∗-algebras [PDF]

open access: yesJournal of Topology and Analysis (JTA), 2016
Classical Spanier–Whitehead duality was introduced for the stable homotopy category of finite CW complexes. Here we provide a comprehensive treatment of a noncommutative version, termed Spanier–Whitehead [Formula: see text]-duality, which is defined on ...
J. Kaminker, Claude L. Schochet
semanticscholar   +1 more source

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood   +6 more
wiley   +1 more source

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

open access: yesNature reviews. Drug discovery, 2021
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront ...
Namit Chaudhary   +2 more
semanticscholar   +1 more source

Firms' Green Responses to Environmental Regulations: A Three‐Dimensional Concurrent Engineering Perspective

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study investigates companies' responses to energy efficiency policies, focusing on mandatory and voluntary regulations that create a complex landscape for businesses to navigate. Using a sample of 1473 firms across 29 European countries (2002–2018), we explore the impact of legislation on green redesign—operationalized through ...
Thomas Alexopoulos   +3 more
wiley   +1 more source

Beyond Structural Interventions: The Human Architecture Shaping ESG Integration in Corporate Systems

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Despite the promotion of ESG in corporate discourse, substantive integration of ESG principles into business practices remains challenging. This study applies and extends Meadows' leverage framework to examine ESG integration in UAE‐listed firms.
M. Schulte, Dimitris Christopoulos
wiley   +1 more source

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