Results 21 to 30 of about 77,413 (314)

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

Nature Communications, 2017
PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition ...
Yu-Xiong Feng, Dexter X. Jin, Ethan S. Sokol, Ferenc Reinhardt, Daniel H. Miller, Piyush B. Gupta   +5 more
doaj   +1 more source

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

Cell Reports, 2020
Summary: The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a role promoting the evolution of new heritable traits.
Peter Tsvetkov, Timothy J. Eisen, Sven U. Heinrich, Zarina Brune, Erinc Hallacli, Greg A. Newby, Can Kayatekin, David Pincus, Susan Lindquist   +8 more
doaj   +1 more source

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

eLife, 2020
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with ...
Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page   +7 more
doaj   +1 more source

¿Existen las máquinas vivientes? Sobre la relación entre vida y técnica

Isegoría, 2016
La biotecnología industrial llama a los productos de la biología sintética “living machines”. Como quiero demostrar en este artículo, la noción de una “máquina viviente” es engañosa.
Stascha Rohmer
doaj   +1 more source

A Rhythmic Process of Harmonization: Whitehead’s Concept of Aesthetic Experience

ESPES, 2023
Book review of Dadejík, O., Kaplický, M., Ševčík, M., and Zuska, V. (2021) Process and Aesthetics: An Outline of Whiteheadian Aesthetics and Beyond. Prague: Karolinum Press. ISBN 978-80-246-4726-5.
Botond Csuka
doaj   +1 more source

Artificial Intelligence Challenges for Knowledge Innovation Cycles

AI &Innovation, EarlyView.
ABSTRACT This article focuses on knowledge innovation and its contemporary reshaping, with particular attention to the growing role of AI in this process. This article first examines the general structure and phases of knowledge innovation cycles, aiming to identify AI's role within them.
Aharon Kellerman
wiley   +1 more source

Analysis and Examination of the Influence of Whitehead's Process Philosophy on Theological Transformation, Focusing on the Issue of "Becoming" [PDF]

Journal of Philosophical Investigations
Alfred North Whitehead's "process philosophy," a novel and influential perspective in contemporary philosophy, examines the organic and interconnected relationships between the various elements of existence and processes.
Mahdi Monazzah, Mohammad Mahdavi, Mohammad Azimi   +2 more
doaj   +1 more source

Pollination by long‐proboscid horseflies and its implications for reproductive isolation among coflowering Satyrium orchids in South Africa

American Journal of Botany, EarlyView.
Abstract Premise Floral adaptations to pollinators can drive lineage diversification and promote coexistence of species. We investigated the reproductive biology of Satyrium longicolle, a South African orchid that we hypothesized to belong to a long‐proboscid horsefly pollination guild and examined overlap of pollinators and floral traits among ...
Steven D. Johnson, Matthew Moir, Ethan Newman, Timotheüs Van der Niet   +3 more
wiley   +1 more source

Dr. Kimberly Whitehead appearance on social and medical justice podcast [PDF]

, 2021
In Episode 18 of Tim Talks, Tim Dentry chats with Kimberly Whitehead, PhD, vice president and chief of staff at the University of Maine, the state\u27s flagship public research university. At the University, Dr.
Whitehead, Kimberly, Dentry, Tim
core  

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source