Results 11 to 20 of about 77,413 (314)

The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

open access: yesNature Communications, 2020
Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a ...
Colin Y. Kim   +5 more
doaj   +1 more source

On Whitehead’s algorithm [PDF]

open access: yesBulletin of the American Mathematical Society, 1984
Using graph theoretic techniques the author generalizes a theorem of Whitehead and a theorem of McCool. More precisely he announces the following. ''One can decide effectively when two finitely generated subgroups of a finitely generated free group F are equivalent under an automorphism of F.
openaire   +3 more sources

Descubrimiento puntos ciegos en la epistemología de los estudios en gestión respecto del currículo del humanismo en administración. Ensayo crítico argumentativo filosófico

open access: yesEstudios Latinoamericanos, 2022
El ensayo argumentativo que se presenta tiene dos fines. Evaluar la suficiencia y compleción de una investigación en administración de operaciones dentro de la epistemología de una escuela de humanismo administrativo, y buscar posibles perspectivas ...
Camilo Osejo-Bucheli
doaj   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

open access: yesLiver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala   +6 more
wiley   +1 more source

m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

open access: yesNature Communications, 2019
Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example ...
G. Guy Bushkin   +7 more
doaj   +1 more source

Dynamic changes in ORC localization and replication fork progression during tissue differentiation

open access: yesBMC Genomics, 2018
Background Genomic regions repressed for DNA replication, resulting in either delayed replication in S phase or underreplication in polyploid cells, are thought to be controlled by inhibition of replication origin activation.
Brian L. Hua   +4 more
doaj   +1 more source

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

open access: yesNature Communications, 2023
Plant biosynthetic enzymes rapidly evolve to catalyze specialized reactions. Here, the authors present the crystal structure and mechanism of COSY, the enzyme involved in coumarin biosynthesis of the BAHD-acyltransferase family that catalyzes an ...
Colin Y. Kim   +7 more
doaj   +1 more source

SYK kinase mediates brown fat differentiation and activation

open access: yesNature Communications, 2017
Spleen protein tyrosine kinase (Syk) has so far been mainly studied in haematopoietic and immune cells. Here, the authors show that Syk also has a role in brown adipose tissue, where it regulates the formation of brown adipocytes and their thermogenic ...
Marko Knoll   +11 more
doaj   +1 more source

New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi

open access: yesmSphere, 2018
We have created new vectors for clustered regularly interspaced short palindromic repeat (CRISPR) mutagenesis in Candida albicans, Saccharomyces cerevisiae, Candida glabrata, and Naumovozyma castellii.
Valmik K. Vyas   +7 more
doaj   +1 more source

Power, Possibility, and Agency: Speculative Realism and Whitehead’s Theory of Relations

open access: yesEidos. A Journal for Philosophy of Culture, 2020
At the turn of the twentieth century, the debate between supporters of internal and external relations showed how our assumptions on the nature of relations result in ontological, epistemic, and ethical commitments. In this debate, Alfred North Whitehead
Christian Frigerio
doaj   +1 more source

Home - About - Disclaimer - Privacy