Results 191 to 200 of about 3,975,496 (251)

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu, Nur Mohammad, Fahad Ahmed, Towsif Alam, Koushik Saha, Durga Shahi, Adib Hossain, Mia Md. Tofayel Gonee Manik, Mst. Rina Parvin   +8 more
wiley   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah, Mohanad Sameer Jabbar, Saif H. Alwaeli, Noor Ayesha, Mohamed Babiker A. Mohamed, Muhammad I. Khan   +5 more
wiley   +1 more source

Asymptomatic Cardiotoxicity After High‐Dose Anthracycline Treatment in Sarcoma Patients Assessed by Biomarkers and Echocardiography

International Journal of Cancer, Volume 159, Issue 11, Page 2755-2765, 1 December 2026.
ABSTRACT Treatment of sarcoma includes high‐dose anthracyclines, which can cause cardiotoxicity. This study assesses the correlation of cardiac biomarkers and echocardiographic parameters on asymptomatic cardiotoxicity in sarcoma patients treated with anthracyclines.
Elissa A. S. Polomski, Frank M. Speetjens, J. Wouter Jukema, Julius C. Heemelaar, Michiel A. J. van de Sande, Hans Gelderblom, M. Louisa Antoni   +6 more
wiley   +1 more source

Distinct Epigenetic Responses to Aging and Short‐Term High‐Fat Diet in Hepatic Lipid Metabolism Genes in Male and Female Mice

Liver International Communications, Volume 7, Issue 4, December 2026.
ABSTRACT Background and Aims Aging is associated with widespread epigenetic remodelling that contributes to metabolic alterations in the liver. High‐fat diet (HFD) represents a major environmental perturbation affecting hepatic metabolism, yet its specific impact on age‐associated epigenetic changes remains unclear.
Annalena Frank, Sascha Tierling, Beate Czepukojc, Sonja M. Kessler, Thomas Hentrich, Michael Kohlstedt, Johannes Haybaeck, Christoph Wittmann, Jessica Hoppstädter, Julia Schulze‐Hentrich, Alexandra K. Kiemer   +10 more
wiley   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Association Between BMI and the Efficacy and Safety of CDK4/6 Inhibitors in HR+/HER2− Advanced Breast Cancer: A Multicenter Retrospective Propensity Score Matched Cohort Study (CAMELIA)

MedComm – Oncology, Volume 5, Issue 4, December 2026.
This multicenter real‐world study showed that higher BMI (≥ 25 kg/m2) was independently associated with improved PFS in patients with HR+/HER2− advanced breast cancer receiving CDK4/6 inhibitors. Safety outcomes were comparable between BMI groups, and the findings were consistent across alternative BMI thresholds, suggesting the potential prognostic ...
Min Tian, Yijia Hua, Qian Liu, Nan Jin, Xinyu Wu, Kun Wang, Min Yan, Tao Sun, Chunfang Hao, Yanxia Zhao, Wei Li, Xiang Huang, Yongmei Yin   +12 more
wiley   +1 more source

Per‐Channel Complex B1+$$ {B}_1^{+} $$ Mapping for Parallel Transmit Ultra‐High Field MRI

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
Transmit‐field inhomogeneities beset ultra‐high field (UHF) MRI scans using single‐channel transmission or circularly polarised (CP) mode. Parallel transmission mitigates these artefacts but requires accurate subject‐specific per‐channel complex (magnitude and phase) B1+$$ {B}_1^{+} $$ maps. We explain the theory of per‐channel complex B1+$$ {B}_1^{+} $
Ye Yuan, Jianxiang Chen, Christopher T. Rodgers   +2 more
wiley   +1 more source

Whole‐Brain 4D MRA With Improved Vessel Delineation Using Undersampled Multiple Overlapping Thin‐Slab Radial Acquisition

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
A noncontrast‐enhanced 4D MRA technique by integrating pulsed ASL with undersampled multiple overlapping thin‐slab stack‐of‐stars golden‐angle radial acquisition is developed for the evaluation of whole‐brain arterial flow dynamics with improved vessel delineation. The proposed method substantially reduced RF saturation effects and preserved signals in
Tianrui Zhao, Sang Hun Chung, Yining He, Ziyi Huang, Jianing Tang, Sameer A. Ansari, Lirong Yan   +6 more
wiley   +1 more source

Cancer Neuroscience: From Hallmark‐Enabling Biology to a Therapeutic Pillar

Advanced Oncology, Volume 1, Issue 1, December 2026.
Moran Amit
wiley   +1 more source

Quantitative Chemical Exchange Saturation Transfer Imaging With Golden‐Angle Radial k‐Space Sampling and Locally Low‐Rank Reconstruction

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
A radial CEST‐MR Fingerprinting method is demonstrated that avoids EPI distortion using low‐rank reconstruction and neural network quantification. It produced accurate 3D brain CEST maps in 11 min, with simulation errors below 14%, strong agreement with conventional fitting, high reproducibility (ICC up to 0.92), and limited motion‐related errors.
Ouri Cohen, Elizabeth J. Sutton, Robert J. Young, Ricardo Otazo   +3 more
wiley   +1 more source