Results 201 to 210 of about 3,975,496 (251)

2D U‐Net Framework for Multiclass Automated Segmentation of Healthy Structures, Ischemic Stroke, and Glioblastoma in the Rat Brain

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
A multitask 2D U‐Net framework enabling automated, accurate segmentation and quantification of rodent brain regions, stroke lesions, and tumors from MRI data. ABSTRACT Rodents are essential for preclinical brain disease research, including stroke, tumors, and neurodegenerative disorders.
Sara Ortega‐Espina, Sabela Fernández‐Rodicio, María Luz Alonso‐Alonso, Pelayo García‐Acevedo, Ana Sampedro‐Viana, Marcos Bazarra‐Barreiros, María Teresa Abengoza‐Bello, Antonio J. Mosqueira, Jacobo Porto‐Álvarez, Javier Martínez Fernández, Crhistian‐Mario Oblitas, José Castillo, Pablo Hervella, Ramón Iglesias‐Rey   +13 more
wiley   +1 more source

Bone Marrow Fibrosis as a Predictor of Extramedullary Disease in Multiple Myeloma

European Journal of Haematology, Volume 117, Issue 6, Page 1659-1664, December 2026.
ABSTRACT The correlation between bone marrow fibrosis (BMF) and extramedullary disease has yet to be fully elucidated in patients with newly diagnosed multiple myeloma. Therefore, we aimed to analyze the incidence of BMF in newly diagnosed multiple myeloma patients and evaluate the relationship between BMF and synchronous soft tissue extramedullary ...
Hilal Senkal, Ali Yilmaz Altay, Emine Goknur Isik, Simge Erdem, Metban Mastanzade, Gulcin Yegen, Mustafa Murat Ozbalak, İpek Yonal Hindilerden, Mustafa Nuri Yenerel, Sevgi Kalayoglu Besisik   +9 more
wiley   +1 more source

Bispecific antibodies targeting B‐cell maturation antigen in multiple myeloma: Current clinical applications, challenges and future directions

Cancer, Volume 132, Issue 22, 15 November 2026.
Abstract Anti‐B cell maturation antigen (BCMA) therapies, including antibody‐drug conjugates, chimeric antigen receptor T cells, and bispecific antibodies (bsAbs), have recently revolutionized the treatment landscape of multiple myeloma. This review outlines the biologic rationale for targeting BCMA and sheds light on the mechanism of action of bsAbs ...
Enrica Manzato, Gloria Cocchetto, Simona Barbato, Michele Puppi, Simone Masci, Elena Zamagni   +5 more
wiley   +1 more source

Longitudinal Associations Between Inflammation and Multi‐Dimensional Fatigue up to 2 Years After Colorectal Cancer Diagnosis

International Journal of Cancer, Volume 159, Issue 10, Page 2437-2451, 15 November 2026.
Cancer‐related fatigue (CRF) is a common and debilitating symptom among colorectal cancer (CRC) patients, but its underlying biological causes remain unclear, with inflammation emerging as a leading suspect. Here, researchers analyzed inflammatory biomarkers in blood samples and evaluated responses in fatigue assessments from CRC patients at and up to ...
Anouk E. C. Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans   +3 more
wiley   +1 more source

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Whole brain radiotherapy for brain metastases

BMJ, 2016
Optimising its use and application in the context of new treatments A recent large non-inferiority trial reported that whole brain radiotherapy did not improve survival or quality of life in adults with brain metastases from non-small cell lung cancer, when compared with corticosteroids and supportive care.1 QUARTZ (Quality of Life after Treatment ...
Orit, Kaidar-Person, Carey K, Anders, Timothy M, Zagar   +2 more
openaire   +4 more sources

Hippocampus sparing in whole-brain radiotherapy

Strahlentherapie und Onkologie, 2014
Radiation treatment techniques for whole-brain radiation therapy (WBRT) have not changed significantly since development of the procedure. However, the recent development of novel techniques such as intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT) and helical tomotherapy, as well as an increasing body of evidence ...
F, Oskan, U, Ganswindt, S B, Schwarz, F, Manapov, C, Belka, M, Niyazi   +5 more
openaire   +2 more sources

Role of Whole-Brain Radiotherapy

2020
Whole-brain radiotherapy (WBRT) has been integral to the management of brain metastases for several decades. Early studies demonstrated the efficacy of WBRT in relieving neurologic symptoms related to intracranial disease and improving survival for patients with brain metastases.
Connor Lynch, Jeffrey P. Gross, Vinai Gondi   +2 more
openaire   +1 more source

Whole-Brain Radiotherapy in the Management of Brain Metastasis

Journal of Clinical Oncology, 2006
Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of ...
Deepak, Khuntia, Paul, Brown, Jing, Li, Minesh P, Mehta   +3 more
openaire   +2 more sources

Surgical Resection Followed by Whole Brain Radiotherapy Versus Whole Brain Radiotherapy Alone for Single Brain Metastasis

International Journal of Radiation Oncology*Biology*Physics, 2008
To compare the outcome of surgical resection followed by whole brain radiotherapy (WBRT) with WBRT alone in patients treated for single brain metastasis.The data from 195 patients with single brain metastases were retrospectively evaluated. Of the 195 patients, 99 underwent resection of the metastasis followed by WBRT and 96 underwent WBRT alone. Seven
Dirk, Rades, Susanne, Kieckebusch, Tiina, Haatanen, Radka, Lohynska, Juergen, Dunst, Steven E, Schild   +5 more
openaire   +2 more sources

SURVIVAL OUTCOMES AFTER WHOLE BRAIN RADIOTHERAPY

Neuro-Oncology, 2023
Abstract AIMS Cerebral metastases from extra-cranial primary cancer carries a poor prognosis. For patients in whom surgical resection or SRS are not suitable, local control rates are poor. There is considerable debate surrounding the value of whole brain radiotherapy in this patient cohort in terms of
Andrew Ho, Farasat Kazmi, Hannah Hendry, Pinelopi Gkogkou   +3 more
openaire   +1 more source