Results 51 to 60 of about 3,975,496 (251)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Single institutional outcomes of whole brain radiotherapy for metastatic melanoma brain metastases

Radiation Oncology, 2021
Background The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy.
Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko, Mohammad K. Khan   +3 more
doaj   +1 more source

Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study.

PLoS ONE, 2023
BackgroundRadiotherapy has an important role in the treatment of brain metastases but carries risk of short and/or long-term toxicity, termed radiation-induced brain injury (RBI).
Chen Makranz, Asael Lubotzky, Hai Zemmour, Ruth Shemer, Benjamin Glaser, Jonathan Cohen, Myriam Maoz, Eli Sapir, Marc Wygoda, Tamar Peretz, Noam Weizman, Jon Feldman, Ross A Abrams, Alexander Lossos, Yuval Dor, Aviad Zick   +15 more
doaj   +1 more source

Quality of life among patients with 4 to 10 brain metastases after treatment with whole-brain radiotherapy vs. stereotactic radiotherapy: a phase III, randomized, Dutch multicenter trial [PDF]

Background : Stereotactic radiotherapy (SRT) is an attractive treatment option for patients with brain metastases (BM), sparing healthy brain tissue and likely controlling local tumors.
Bruynzeel, Anna, Eekers, Danielle, Hurkmans, Coen, Swaak-Kragten, Annemarie, Verhoeff, Joost J.C., Wiggenraad, Ruud, Swinnen, Ans, Dieleman, Edith, van der Toorn, Peter Paul, van Veelen, Lieneke, Hartgerink, Dianne, Lambin, Philippe, Zindler, Jaap, de Ruysscher, Dirk, Lagerwaard, Frank   +14 more
core   +1 more source

Right Treatment Wrong Time: Immunotherapy Administration Post-Radiotherapy Decreases Tumor Burden in a Preclinical Model of Brain Metastasis [PDF]

, 2023
This dissertation (a) provided an in-depth literature review of methods to modulate the blood-brain and blood-tumor barriers to increase drug delivery and efficacy in brain metastases, (b) evaluated the effects of whole-brain radiation therapy on the ...
Blethen, Kathryn Elizabeth
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Dosimetric Comparison between Simultaneous Integrated Boost Dynamic Conformal Arc Therapy and Whole Brain Radiation Therapy Techniques in Treatment of Patients with Multiple Brain Metastases [PDF]

Egyptian Journal of Cancer and Biomedical Research
Background: Whole Our study aims to compare between the dosimetric results and treatment delivery efficiency of Whole Brain Radiation Therapy (WBRT) versus Simultaneous Integrated Boost Dynamic Conformal Arc Therapy (DCAT) planning techniques – to ...
Ahmed ElDrieny, Ahmed Ahmed, Nayera Mahmoud, Azza Darwish   +3 more
doaj   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Whole brain radiotherapy (WBRT) after local treatment of brain metastases in melanoma patients: Statistical Analysis Plan

Trials, 2019
Background The WBRTMel trial is a multinational, open-label, phase III randomised controlled trial comparing whole brain radiotherapy (WBRT) to observation following local treatment of one to three melanoma brain metastases with surgery and/or ...
Serigne N. Lo, Angela M. Hong, Lauren E. Haydu, Tasnia Ahmed, Elizabeth J. Paton, Victoria Steel, George Hruby, Anh Tran, Rachael L. Morton, Anna K. Nowak, Janette L. Vardy, Katharine J. Drummond, Haryana M. Dhillon, Catherine Mandel, Richard A. Scolyer, Mark R. Middleton, Bryan H. Burmeister, John F. Thompson, Gerald B. Fogarty   +18 more
doaj   +1 more source

Re-irradiation for Metastatic Brain Tumors with Whole-brain Radiotherapy [PDF]

Japanese Journal of Clinical Oncology, 2012
To determine whether second whole-brain irradiation is beneficial for patients previously treated with whole-brain irradiation.A retrospective analysis was done for 31 patients with brain metastases who had undergone re-irradiation. Initial whole-brain irradiation was performed with 30 Gy/10 fractions for 87% of these patients.
Takeshi, Akiba, Etsuo, Kunieda, Asuka, Kogawa, Tetsuya, Komatsu, Yoshifumi, Tamai, Yukio, Ohizumi   +5 more
openaire   +2 more sources