Results 61 to 70 of about 3,975,496 (251)

Focal cavity radiotherapy after neurosurgical resection of brain metastases: sparing neurotoxicity without compromising locoregional control [PDF]

, 2022
PURPOSE: Does focal cavity radiotherapy after resection of brain metastasis “spare” whole-brain radiotherapy, which is associated with toxicity for patients, through the complete course of their disease without compromising long-term local control of the
Berlis, Ansgar, Kahl, Klaus-Henning, Janzen, Tilman, Maurer, Christoph J., Shiban, Ehab, Müller, Heiko, Kahl, Klaus Henning, Sommer, Björn, Grossert, Ute, Gutser, Susanne, Konietzko, Ina, Stüben, Georg   +11 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues

Angewandte Chemie, EarlyView.
Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar, Zhiming Cheng, Andrew D. M. Green, Sam Benson, Eleni Nestoros, Clarissa Lim, Justyna Cholewa‐Waclaw, Fabio de Moliner, Paula Lusarreta, Deborah Seah, Alsadeg Bilal, Neza Alfazema, Thibaud Aymoz‐Bressot, Gillian Morrison, Sonja Vermeren, Steven M. Pollard, Paul M. Brennan, Michael G. Tanner, Marc Vendrell   +18 more
wiley   +2 more sources

Single-Isocenter Volumetric Modulated Arc Therapy vs. CyberKnife M6 for the Stereotactic Radiosurgery of Multiple Brain Metastases

Frontiers in Oncology, 2020
Introduction: Stereotactic radiosurgery (SRS) is becoming more frequently used for patients with multiple brain metastases (BMs). Single-isocenter volumetric modulated arc therapy (SI-VMAT) is an emerging alternative to dedicated systems such as ...
Rami A. El Shafie, Rami A. El Shafie, Eric Tonndorf-Martini, Eric Tonndorf-Martini, Daniela Schmitt, Daniela Schmitt, Aylin Celik, Aylin Celik, Dorothea Weber, Kristin Lang, Kristin Lang, Laila König, Laila König, Simon Höne, Simon Höne, Tobias Forster, Tobias Forster, Bastian von Nettelbladt, Bastian von Nettelbladt, Sebastian Adeberg, Sebastian Adeberg, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Stefan Rieken, Stefan Rieken, Stefan Rieken, Denise Bernhardt, Denise Bernhardt   +29 more
doaj   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Postoperative Whole-Brain Radiotherapy (ESTRON)—A Single-Center Prospective Randomized Trial

, 2018
Neurosurgical resection is recommended for symptomatic brain metastases, in oligometastatic patients or for histology acquisition. Without adjuvant radiotherapy, roughly two-thirds of the patients relapse at the resection site within 24 mo, while the ...
Hauswald, Henrik, Paul, Angela, Stefan Rieken, Henrik Hauswald, Meinhard Kieser, Sebastian Klüter, Klose, Christina, Kai Schubert, Hommertgen, Adriane, Krisam, Johannes, Denise Bernhardt, Debus, Jürgen, El Shafie, Rami A., Schmitt, Daniela, Schubert, Kai, Christina Klose, Welzel, Thomas, Rami A El Shafie, Angela Paul, Johannes Krisam, Klüter, Sebastian, Jürgen Debus, Rieken, Stefan, Daniela Schmitt, Tanja Sprave, Sprave, Tanja, Thomas Welzel, Kieser, Meinhard, Bernhardt, Denise, Adriane Hommertgen   +29 more
core   +1 more source

Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study

, 2020
Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care for patients with small cell lung cancer.
Robin, Tyler P, Yomo, Shoji, Grills, Inga S, Niranjan, Ajay, Silverman, Joshua S, Aiyama, Hitoshi, Guckenberger, Matthias, Verma, Vivek, Sato, Yasunori, Singh, Charu, Combs, Stephanie, Palmer, Joshua D, Braunstein, Steve, Smith, Derek E, Lunsford, L Dade, Seto, Takahashi, Warnick, Ronald E, Attia, Albert, Yu, James B, Chiang, Veronica, Andratschke, Nicolaus, McInerney, James, Rieken, Stefan, Kavanagh, Brian D, Cifarelli, Christopher P, Sheehan, Jason P, Brown, Paul D, Chan, Michael D, Serizawa, Toru, Cordeiro, Diogo, Higuchi, Yoshinori, Day, Samuel, Kondziolka, Douglas, Deibert, Christopher P, Gao, Dexiang, Lee, Cheng-Chia, Siddiqui, Zaid A, Zacharia, Brad E, Rusthoven, Chad G, Yuan, Justin C, Li, Benjamin, Yamamoto, Masaaki, Nosaki, Kename, Kessel, Kerstin A, Patel, Samir, Trifiletti, Daniel M, Cagney, Daniel N, Shuto, Takashi, Halasz, Lia M, Touchette, Charles J, Vargo, John A, Bernstein, Kenneth, Yang, Huai-Che, Mathieu, David, Tuanquin, Leonard C, Faramand, Andrew M, Bernhardt, Denise, Aizer, Ayal A, Akabane, Atsuya   +58 more
core   +1 more source

Recent Update on Neurosurgical Management of Brain Metastasis [PDF]

, 2022
Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months.
박현호, 장종희, 강석구, 유지환   +3 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source