Results 81 to 90 of about 3,975,496 (251)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma

Radiation Oncology, 2012
Background To retrospectively access outcome and toxicity of whole brain radiotherapy (WBRT) in patients with multiple brain metastases (BM) from malignant melanoma (MM).
Hauswald Henrik, Dittmar Jan-Oliver, Habermehl Daniel, Rieken Stefan, Sterzing Florian, Debus Jürgen, Combs Stephanie E   +6 more
doaj   +1 more source

Palliative whole-brain radiotherapy and health-related quality of life for patients with brain metastasis in cancer

, 2015
Ying Gao,1,* Fei Gao,2,* Jin-lu Ma,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University, Xi’an ...
Ma JL, Gao Y, Gao F, Zhao DL
core  

Parotid glands in whole-brain radiotherapy: 2D versus 3D technique for no sparing or sparing

, 2015
PURPOSE: Whole-brain radiotherapy is performed as standard therapy in patients with multiple brain metastases and in patients with more favourable prognosis such as lymphoma and small-cell lung carcinoma in the prophylactic setting.
Di Pilla, A, Augurio, A, DI TOMMASO, MONICA, DI NICOLA, MARTA, VINCIGUERRA, ANNAMARIA, TRIGNANI, MARIANNA, GENOVESI, Domenico, Cèfaro, G. A   +7 more
core   +1 more source

Whole-brain fMRI analyses results.

, 2021
Whole-brain fMRI analyses results.
Frederike Beyer (590367), Axel Cleeremans (187360), Emilie A. Caspar (9955480), Patrick Haggard (264440)   +3 more
core   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Is Whole‐Brain Radiotherapy for Brain Metastases an Overestimated Therapy? A Retrospective Study of Real‐World Data Using Landmark Analyses

Cancer Medicine
Background The role of whole‐brain radiotherapy for patients with brain metastases is changing as immunotherapy and molecularly targeted therapies advance. However, whole‐brain radiotherapy continues to be part of the multimodal concept.
Florian Hoelzl, Oliver Koelbl, Isabella Gruber   +2 more
doaj   +1 more source

Meta‐analysis of whole‐brain radiotherapy plus temozolomide compared with whole‐brain radiotherapy for the treatment of brain metastases from non‐small‐cell lung cancer

Cancer Medicine, 2018
The aim of this meta‐analysis was to compare the efficiency of whole‐brain radiotherapy (WBRT) plus temozolomide (TMZ) with WBRT for the treatment of brain metastases from non‐small‐cell lung cancer (NSCLC).
Yong Xin, WenWen Guo, Chun Sheng Yang, Qian Huang, Pei Zhang, Long Zhen Zhang, Guan Jiang   +6 more
doaj   +1 more source

Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma

, 2013
Hongqing Zhuang,1–4 Zhiyong Yuan,1–4 Jun Wang,1–4 Lujun Zhao,1–4 Qingsong Pang,1–4 Ping Wang1–41Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, 2National Clinical Research Center ...
Zhao L, Wang P, Pang Q, Zhuang H, Wang J, Yuan Z   +5 more
core  

The treatment of patients with 1-3 brain metastases: is there a place for whole brain radiotherapy alone, yet? A retrospective analysis

, 2015
To evaluate the efficacy of whole brain radiotherapy (WBRT) with or without other treatments in patients (pts) with 1-3 brain metastases (BM)
PEDRETTI, Sara, PADOVANI, Alessandro, Buttolo, Luciano, BUGLIONE DI MONALE E BASTIA, Michela, POLIANI, Pietro Luigi, PEGURRI, Ludovica, GHIRARDELLI, Paolo, TRIGGIANI, Luca, BORGHETTI, Paolo, Liserre, Roberto, GIPPONI, Stefano, MAGRINI, Stefano Maria, Panciani, Paolo, Pasinetti, Nadia, PANDINI, Sara Angela, COSTA, Loredana   +15 more
core   +1 more source