Results 41 to 50 of about 77,543 (273)

The comet assay in oral leucocytes: a non-invasive alternative in human studies?

Frontiers in Genetics, 2015
The comet assay is the method of choice for measuring DNA damage. In human studies mostly peripheral blood mononuclear cells (PBMC) are used to conduct this single cell gel electrophoresis (Azqueta and Collins, 2013) and also a method for whole blood was
Annemarie Grindel
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

A Pilot Clinical Study to Investigate the Human Whole Blood Spectrum Characteristics in the Sub-THz Region [PDF]

, 2014
We have conducted a pilot clinical study to not only investigate the THz spectra of ex-vivo fresh human whole blood of 28 patients following 8-hours fasting guideline, but also to find out the critical blood ingredients of which the concentration dominantly affects those THz spectra.
arxiv   +1 more source

Scaling of brain metabolism and blood flow in relation to capillary and neural scaling [PDF]

PLoS ONE 6(10): e26709 (2011), 2011
Brain is one of the most energy demanding organs in mammals, and its total metabolic rate scales with brain volume raised to a power of around 5/6. This value is significantly higher than the more common exponent 3/4 relating whole body resting metabolism with body mass and several other physiological variables in animals and plants.
arxiv   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins

Frontiers in Aging Neuroscience, 2017
As the world's population ages, the age-related cognitive decline presents a great challenge to world's healthcare systems. One of the molecular mechanisms implicated in cognitive ageing is DNA methylation, an epigenetic modification known to be a key ...
Anna Starnawska, Anna Starnawska, Anna Starnawska, Qihua Tan, Qihua Tan, Matt McGue, Matt McGue, Ole Mors, Ole Mors, Ole Mors, Anders D. Børglum, Anders D. Børglum, Anders D. Børglum, Kaare Christensen, Kaare Christensen, Kaare Christensen, Kaare Christensen, Mette Nyegaard, Mette Nyegaard, Mette Nyegaard, Lene Christiansen, Lene Christiansen   +21 more
doaj   +1 more source

Protective Effect of Silibinin on Lipopolysaccharide-Induced Inflammatory Responses in Equine Peripheral Blood Mononuclear Cells, an In Vitro Study

Animals, 2020
Although inflammation is an important physiological response, it plays a prominent role in several diseases across the mammalian species. In horses, in particular, inflammation secondary to bacterial infection or translocation is one of the most frequent
Enrico Gugliandolo, Rosalia Crupi, Vito Biondi, Patrizia Licata, Salvatore Cuzzocrea, Annamaria Passantino   +5 more
doaj   +1 more source

Murray's law revisited: Quémada's fluid model and fractal trees [PDF]

J. Rheol. 59, 1419 (2015), 2015
In 1926, Murray proposed the first law for the optimal design of blood vessels. He minimized the power dissipation arising from the trade-off between fluid circulation and blood maintenance. The law, based on a constant fluid viscosity, states that in the optimal configuration the fluid flow rate inside the vessel is proportional to the cube of the ...
arxiv   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Noninvasive In vivo Estimation of HbA1c Based on Beer Lambert Model from Photoplethysmogram Using Only Two Wavelengths [PDF]

Applied Sciences 13, no. 6 (2023): 3626
Glycated hemoglobin (HbA1c) is the most important factor in diabetes control. Since HbA1c reflects the average blood glucose level over the preceding three months, it is unaffected by the patient's activity level or diet before the test. Noninvasive HbA1c measurement reduces both the pain and complications associated with fingertip piercing to collect ...
arxiv   +1 more source