Results 61 to 70 of about 157,765 (267)

The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication [PDF]

, 2008
Gene duplication is an important mechanism in the evolution of protein interaction networks. Duplications are followed by the gain and loss of interactions, rewiring the network at some unknown rate.
A. Presser, Barabasi, Batada, Baur, Dehal, Guldener, Ho, Hughes, Ispolatov, Jaillon, Kafri, Kellis, Langkjaer, M. B. Elowitz, M. Kellis, Marianayagam, Milo, Musso, Papp, Pastor-Satorras, Pereira-Leal, R. Kishony, Salwinski, Scannell, Tirosh, Uetz, Wagner, Wagner, Wapinski, Wolfe, Wolfe, Xenarios, Xenarios, Xenarios   +33 more
core   +3 more sources

Expansive evolution of the TREHALOSE-6-PHOSPHATE PHOSPHATASE gene family in Arabidopsis [PDF]

, 2012
Trehalose is a nonreducing sugar used as a reserve carbohydrate and stress protectant in a variety of organisms. While higher plants typically do not accumulate high levels of trehalose, they encode large families of putative trehalose biosynthesis genes.
Avonce, Nelson, Beeckman, Tom, Feil, Regina, Lammens, Willem, Lopez Galvis, Lorena, Lunn, John E, Maere, Steven, Rolland, Filip, Van Dijck, Patrick, Vandesteene, Lies, Vanneste, Kevin   +10 more
core   +2 more sources

Whole genome duplications in plants: an overview fromArabidopsis [PDF]

Journal of Experimental Botany, 2015
Polyploidy is a common event in plants that involves the acquisition of more than two complete sets of chromosomes. Allopolyploidy originates from interspecies hybrids while autopolyploidy originates from intraspecies whole genome duplication (WGD) events.
Pozo, José Luis del, Ramírez-Parra, Elena   +1 more
openaire   +3 more sources

The impact of genome triplication on tandem gene evolution in Brassica rapa

Frontiers in Plant Science, 2012
Whole genome duplication (WGD) and tandem duplication (TD) are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied.
Lu eFang, Feng eCheng, Jian eWu, Xiaowu eWang   +3 more
doaj   +1 more source

On the origins of Mendelian disease genes in man: the impact of gene duplication [PDF]

, 2011
Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically ...
Dickerson, Jonathan E., Robertson, David L.   +1 more
core   +1 more source

A case of recurrent epilepsy-associated rosette-forming glioneuronal tumor with anaplastic transformation in the absence of therapy. [PDF]

, 2019
Rosette-forming glioneuronal tumor (RGNT) most commonly occurs adjacent to the fourth ventricle and therefore rarely presents with epilepsy. Recent reports describe RGNT occurrence in other anatomical locations with considerable morphologic and genetic ...
Corless, Christopher L, Ferris, Sean P, Grafe, Marjorie, Gultekin, Sakir H, Halfpenny, Aaron, Lawce, Helen, Lucas, Lora, Moore, Stephen, Nazemi, Kellie, Olson, Susan, Perry, Arie, Selden, Nathan, Solomon, David A, Woltjer, Randy, Wood, Matthew D   +14 more
core   +1 more source

Implementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory [PDF]

, 2016
Objectives: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15-month experience on clinical samples.
De Smet, Matthias, Dheedene, Annelies, Grisart, Bernard, Janssens, Sandra, Menten, Björn, Sante, Tom, Vanbellinghen, Jean-François, Vergult, Sarah   +7 more
core   +2 more sources

Relaxation of yeast mitochondrial functions after whole-genome duplication [PDF]

Genome Research, 2008
Mitochondria are essential for cellular energy production in most eukaryotic organisms. However, when glucose is abundant, yeast species that underwent whole-genome duplication (WGD) mostly conduct fermentation even under aerobic conditions, and most can survive without a functional mitochondrial genome.
Huifeng, Jiang, Wenjun, Guan, David, Pinney, Wen, Wang, Zhenglong, Gu   +4 more
openaire   +2 more sources

Model-Based Detection of Whole-Genome Duplications in a Phylogeny [PDF]

Molecular Biology and Evolution, 2020
Abstract Ancient whole-genome duplications (WGDs) leave signatures in comparative genomic data sets that can be harnessed to detect these events of presumed evolutionary importance. Current statistical approaches for the detection of ancient WGDs in a phylogenetic context have two main drawbacks.
Zwaenepoel, Arthur, Van de Peer, Yves
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source