Results 41 to 50 of about 533,077 (310)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Whole-genome sequencing data of Kazakh individuals

BMC Research Notes, 2021
Objectives Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today is the multi-ethnic country with ...
Ulykbek Kairov, Askhat Molkenov, Saule Rakhimova, Ulan Kozhamkulov, Aigul Sharip, Daniyar Karabayev, Asset Daniyarov, Joseph H.Lee, Joseph D.Terwilliger, Ainur Akilzhanova, Zhaxybay Zhumadilov   +10 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Multi-country and intersectoral assessment of cluster congruence between pipelines for genomics surveillance of foodborne pathogens

Nature Communications
Different laboratories employ different Whole-Genome Sequencing (WGS) pipelines for Food and Waterborne disease (FWD) surveillance, casting doubt on the comparability of their results and hindering optimal communication at intersectoral and international
Verónica Mixão, Miguel Pinto, Holger Brendebach, Daniel Sobral, João Dourado Santos, Nicolas Radomski, Anne Sophie Majgaard Uldall, Arkadiusz Bomba, Michael Pietsch, Andrea Bucciacchio, Andrea de Ruvo, Pierluigi Castelli, Ewelina Iwan, Sandra Simon, Claudia E. Coipan, Jörg Linde, Liljana Petrovska, Rolf Sommer Kaas, Katrine Grimstrup Joensen, Sofie Holtsmark Nielsen, Kristoffer Kiil, Karin Lagesen, Adriano Di Pasquale, João Paulo Gomes, Carlus Deneke, Simon H. Tausch, Vítor Borges   +26 more
doaj   +1 more source

Typing methods based on whole genome sequencing data

One Health Outlook, 2020
Whole genome sequencing (WGS) of foodborne pathogens has become an effective method for investigating the information contained in the genome sequence of bacterial pathogens.
Laura Uelze, Josephine Grützke, Maria Borowiak, Jens Andre Hammerl, Katharina Juraschek, Carlus Deneke, Simon H. Tausch, Burkhard Malorny   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Approaches to informed consent for hypothesis-testing and hypothesis-generating clinical genomics research

BMC Medical Genomics, 2012
Background Massively-parallel sequencing (MPS) technologies create challenges for informed consent of research participants given the enormous scale of the data and the wide range of potential results.
Facio Flavia M, Sapp Julie C, Linn Amy, Biesecker Leslie G   +3 more
doaj   +1 more source

Whole-genome sequencing for surveillance of antimicrobial resistance in Ecuador: present and future implications

Revista Panamericana de Salud Pública, 2023
Whole-genome sequencing is becoming the gold standard for pathogen characterization and offers considerable advantages for understanding the evolution and dissemination of new determinants of antimicrobial resistance. Despite the benefits of whole-genome
William Calero-Cáceres, Nimer Ortuño-Gutiérrez, Temmy Sunyoto, Cícero-Armídio Gomes-Dias, Carlos Bastidas-Caldes, Ma. Soledad Ramírez, Anthony D. Harries   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source