Results 91 to 100 of about 81,875,801 (209)

Withaferin A decreases glycolytic reprogramming in breast cancer

Scientific Reports
Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan, Asad ur Rehman, Shumaila Siddiqui, Jiyauddin Khan, Sheersh Massey, Prithvi Singh, Daman Saluja, Syed Akhtar Husain, Mohammad Askandar Iqbal   +8 more
openaire   +3 more sources

pH-Responsive Gold Nanoparticle/PVP Nanoconjugate for Targeted Delivery and Enhanced Anticancer Activity of Withaferin A

The development of advanced high-capacity nanoparticle-based drug loading, precise targeting, low toxicity, and excellent biocompatibility is critical for improving cancer therapeutics.
Paulraj Arunkumar, Amutha Santhanam, Velmurugan Sekar   +2 more
core   +1 more source

Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice

, 2018
The increasing global prevalence of obesity and its associated disorders point to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss.
Lee, Jaemin, Mucka, Patrick, Ibi, Dorina, Feng, Xudong, Choi, Jae Won, Ozcan, Umut, Liu, Junli, Salazar Hernández, Mario Andrés   +7 more
core   +1 more source

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Molecular Cancer, 2010
Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah, Zhokhov Sergey, Palagani Ajay, Poompimon Wilart, Mankhetkorn Samlee, Suttana Wipob, Haegeman Guy, Berghe Wim   +7 more
doaj   +1 more source

Implications of Withaferin A in neurological disorders

Neural Regeneration Research, 2021
Natasha Ram, Stephanie L Peak, Andres R Perez, Umesh K Jinwal   +3 more
openaire   +3 more sources

Glioblastoma Stem Cells and Withaferin A, A Review [PDF]

Biomedical Journal of Scientific & Technical Research, 2019
Glioblastoma multiforme is characterized by tumor cell heterogeneity, and by recurrent invasive tumors following conventional radiation, cytotoxic drugs, and limited ablative surgery [1-5]...
openaire   +1 more source

Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach

, 2019
To cope with the poor aqueous solubility of withaferin A, a broad-spectrum anti-cancer agent effective against therapy-resistant cancers, a polymer-drug conjugate was synthesized via a grafting-from-drug approach.
Vanden Berghe, Tom, De Geest, Bruno, Hassannia, Behrouz, Van Herck, Simon, Louage, Benoit, De Geest, Bruno G., De Coen, Ruben, Pita Compostizo, Raquel, Vanden Berghe, Wim   +8 more
core   +1 more source

Data from SILAC-based quantitative analysis of lysates from mouse microglial cells treated with Withaferin A (WA)

Data in Brief, 2016
Mass spectrometry data collected in a study analyzing the effect of withaferin A (WA) on a mouse microglial (N9) cell line is presented in this article.
Malathi Narayan, Kent W. Seeley, Umesh K. Jinwal   +2 more
doaj   +1 more source

Protective Effect Of Withaferin-A On Micronucleus Frequency And Detoxication Agents During Experimental Oral Carcinogenesis

, 2009
Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, Kuppusamy, Manoharan, Shanmugam, Balakrishnan, Subramanian, Suresh, Kathiresan, Alias, Namasivayam Senthiland Linsa Marry, Nirmal, Madhavan R.   +5 more
core   +2 more sources

Apoptosis is Induced in leishmanial Cells by a Novel Protein Kinase Inhibitor Withaferin A and is Facilitated by Apoptotic Topoisomerase I–DNA complex

, 2007
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. We report here that like staurosporine, withaferin A is a potent inhibitor of PKC.
Sen, T, Pramanik, S, Mukhopadhyay, S, Mukhopadhyay, S., H K Majumder, Sen, T., B Banerjee, Das, B. B., Banerjee, B, S Mukhopadhyay, Majumder, H. K., N Sen, Sen, N., B B Das, A Ganguly, Banerjee, B., Ganguly, A., Majumder, Hemanta K, Sen, N, Pramanik, S., Ganguly, A, T Sen, S Pramanik   +22 more
core   +1 more source