Cells, 2022 Background: Retinal ischemia-reperfusion (I/R) injury often results in intractable visual impairments. The survival of retinal capillary endothelial cells is crucial for the treatment of retinal I/R injury.
Zheyi Yan +6 more
doaj +2 more sources
Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
exaly +3 more sources
Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling
Journal of Ovarian Research, 2019 Background Ovarian cancer is the fifth leading cause of cancer-related deaths amongst women in the United States. Cachexia is the primary cause of death in approximately 30% of cancer patients, and is often evidenced in ovarian cancer patients. We tested
Alex R. Straughn, Sham S. Kakar
doaj +2 more sources
Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
Frontiers in Oncology, 2021 Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Divya P Kumar +2 more
exaly +3 more sources
Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. [PDF]
PLoS ONE, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Zhen Yang +6 more
doaj +3 more sources
Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling [PDF]
Bangladesh Journal of Pharmacology, 2014 Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays.
Yang Chen +4 more
doaj +2 more sources
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
Archives of Medical ScienceIntroduction Withaferin-A (WA) derived from natural products can inhibit the growth and metastasis of colorectal cancer (CRC) in vitro and in vivo. Transcriptome sequencing showed that WA inhibited the epithelial-mesenchymal transition pathway (EMT ...
Wen-qi Lu +6 more
doaj +2 more sources
Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation
Heliyon, 2021 Standardization is an important measurement for ensuring the quality control of herbal drugs. It has become essential to develop reliable, specific and sensitive quality control methods.
Ajay Kumar Meena
exaly +3 more sources
Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid-Liquid Extracts from <i>Withania somnifera</i>. [PDF]
Plants (Basel)Ethnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Culurciello R +9 more
europepmc +2 more sources
Formulation and <i>In Vitro</i> Characterisation of Withaferin A-Loaded Liposomal Gels for the Topical Management of Chronic Inflammatory Skin Conditions. [PDF]
Br J Biomed SciChronic inflammatory skin conditions such as psoriasis, eczema, and acne are driven by sustained inflammation, oxidative stress, and impaired tissue repair.
Marwah MK +6 more
europepmc +2 more sources