Formulation and In Vitro Characterisation of Withaferin A-Loaded Liposomal Gels for the Topical Management of Chronic Inflammatory Skin Conditions [PDF]
British Journal of Biomedical ScienceChronic inflammatory skin conditions such as psoriasis, eczema, and acne are driven by sustained inflammation, oxidative stress, and impaired tissue repair.
Mandeep Kaur Marwah +6 more
doaj +2 more sources
Obesity: will withaferin win the war?
Nature Medicine, 2016 A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits in mice, including body-weight loss, reduced hepatic steatosis and improved glucose control.
Paul T Pfluger, Matthias H Tschöp
openaire +5 more sources
Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A
Journal of Pharmacy & Pharmaceutical Sciences, 2009 Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity.
Mahaboobkhan Rasool +2 more
doaj +2 more sources
In Silico Identification of Plant-Derived GPX4 Inhibitors as Potential Ferroptosis Inducers: Molecular Docking, Dynamics, and ADMET Studies [PDF]
Current Issues in Molecular BiologyThis study aims identify plant-derived compounds that can inhibit glutathione peroxidase 4 (GPX4) enzyme and evaluate them through molecular docking, dynamics simulations, and ADMET analyses.
Şerife Efsun Antmen +3 more
doaj +2 more sources
Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal [PDF]
Pharmaceuticals, 2023 Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar +9 more
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Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review. [PDF]
Phytother ResABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Williamson EM, Brendler T.
europepmc +2 more sources
Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas [PDF]
MoleculesAyurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Herbert B. Newton
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Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]
Journal of Ayurveda and Integrative MedicineBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe +4 more
doaj +2 more sources
Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations [PDF]
Scientific ReportsEnterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
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Withaferin A Associated Differential Regulation of Inflammatory Cytokines [PDF]
Frontiers in Immunology, 2018 A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary ...
Seema Dubey +5 more
doaj +3 more sources