Results 101 to 110 of about 114,628,411 (160)

Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Apoptosis is Induced in leishmanial Cells by a Novel Protein Kinase Inhibitor Withaferin A and is Facilitated by Apoptotic Topoisomerase I–DNA complex

, 2007
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. We report here that like staurosporine, withaferin A is a potent inhibitor of PKC.
Sen, T, Pramanik, S, Mukhopadhyay, S, Mukhopadhyay, S., H K Majumder, Sen, T., B Banerjee, Das, B. B., Banerjee, B, S Mukhopadhyay, Majumder, H. K., N Sen, Sen, N., B B Das, A Ganguly, Banerjee, B., Ganguly, A., Majumder, Hemanta K, Sen, N, Pramanik, S., Ganguly, A, T Sen, S Pramanik   +22 more
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Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Journal of Chemistry
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and ...
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal   +10 more
doaj   +1 more source

Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction

, 2019
A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition.
Yogita H. Dahat (6536516), Meenakshi Singh (1645396), Yogesh P. Bharitkar (649975), Ramkrishna Mandal (6536510), Abhijit Hazra (385320), V. Ravichandiran (3864802), Amrutha A.V. Krishnan (6536513)   +6 more
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

Neural Plasticity, 2015
Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. Yet, their contribution to these processes remains mostly elusive. Astroglia
Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Radiosensitization of a mouse melanoma by withaferin A: In vivo studies

, 2000
432-437The radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo.Treatment of 100 mm3 tumours with 10 to 60 mg/kg withaferin A intraperitoneally produced a dose dependent increase in growth delay
Rao, B S Satish, Devi, P Uma, Kamath, Ravindra   +2 more
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Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Mortalin, a target of withanone and withaferin A.

, 2013
Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) in the “latch region” of mortalin (PDB-id: 3N8E). (C) Quantitative analysis of mortalin in human cancer (U2OS) cells treated with various doses of Wi-N and Wi-A. (D) Imaging of mortalin in human
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
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Withaferin a suppresses the expression of vascular endothelial growth factor in ehrlich ascites tumor cells via sp1 transcription factor

, 2009
In the ayurvedic system of medicine, the medicinal plant, Withania somnifera Dunal (Solanaceae) finds application for numerous ailments including cancer.
Bharathi P. Salimath, Prasanna Kumar, S., Shilpa, P.   +2 more
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