Results 11 to 20 of about 3,279 (167)

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition [PDF]

Current Therapeutic Research
Background: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is a well-known plant in ayurvedic medicine, widely valued for its therapeutic potential. Although numerous clinical studies have explored its diverse health benefits, limited data
Priyank Rathi, MD, Se-Kwon Kim, PhD
doaj   +2 more sources

Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC

Frontiers in Oncology, 2021
Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Divya P. Kumar, Faridoddin Mirshahi, Prasanna K. Santhekadur   +4 more
doaj   +1 more source

Discovery of eukaryotic cellular receptor for Withaferin A, a multifaceted drug from Withania somnifera plant

Medicine in Drug Discovery, 2022
Withaferin A is a dietary natural compound from a very popular Ayurvedic plant called Ashwagandha (Withania Somnifera). Since the discovery of Withaferin A and its initial isolation and characterization in 1965, a plethora of elegant molecular and ...
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Prasanna K. Santhekadur   +2 more
doaj   +1 more source

Withaferin a Attenuates Retinal Ischemia-Reperfusion Injury via Akt-Dependent Inhibition of Oxidative Stress

Cells, 2022
Background: Retinal ischemia-reperfusion (I/R) injury often results in intractable visual impairments. The survival of retinal capillary endothelial cells is crucial for the treatment of retinal I/R injury.
Zheyi Yan, Yuanlin Zhang, Chunfang Wang, Yanjie Li, Qiang Su, Jimin Cao, Xiaoming Cao   +6 more
doaj   +1 more source

Withaferin A and Celastrol Overwhelm Proteostasis

International Journal of Molecular Sciences, 2023
Withaferin A (WA) and celastrol (CEL) are major bioactive components of plants that have been widely employed in traditional medicine. The pleiotropic activities of plant preparations and the isolated compounds in vitro and in vivo have been documented in hundreds of studies. Both WA and CEL were shown to have anticancer activity.
Nuria Vilaboa, Richard Voellmy
openaire   +4 more sources

The ameliorating effect of withaferin A on high-fat diet-induced non-alcoholic fatty liver disease by acting as an LXR/FXR dual receptor activator

Frontiers in Pharmacology, 2023
Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Lakshana D. Puttahanumantharayappa, Shreyas H. Karunakara, Smitha Bhat, Shashanka K. Prasad, Shashanka K. Prasad, Divya P. Kumar, Prasanna K. Santhekadur   +8 more
doaj   +1 more source

Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. [PDF]

PLoS ONE, 2010
BACKGROUND:Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ...
Guy Lahat, Quan-Sheng Zhu, Kai-Lieh Huang, Suizhao Wang, Svetlana Bolshakov, Jeffery Liu, Keila Torres, Robert R Langley, Alexander J Lazar, Mien Chie Hung, Dina Lev   +10 more
doaj   +1 more source

Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro

Molecules, 2022
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications.
Itishree Priyadarshini, Subhasmita Swain, Janardhan Reddy Koduru, Tapash Ranjan Rautray   +3 more
doaj   +1 more source

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)

Metabolites, 2022
This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh, Sanjeev Agrawal, Obaid Afzal, Abdulmalik S. A. Altamimi, Alya Redhwan, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Abdelbaset Mohamed Elasbali, Shahanavaj Khan   +9 more
doaj   +1 more source

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

Pharmaceuticals, 2023
Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee   +9 more
doaj   +1 more source