Results 101 to 110 of about 81,875,801 (209)

Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse Model by Downregulation of Cell Signaling Pathway Leading to Invasion and Angiogenesis

, 2015
Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model.Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model.
Wang, YX, Dong, CW, Ding, WB
core   +2 more sources

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology

International Journal of Molecular Sciences, 2019
Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits against many human illnesses such as epilepsy, depression, arthritis, diabetes, and palliative effects such as analgesic, rejuvenating ...
Dutta, Rinku, Khalil, Roukiah, Green, Ryan, Mohapatra, Shyam S, Mohapatra, Subhra   +4 more
openaire   +2 more sources

Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction

, 2019
A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition.
Yogita H. Dahat (6536516), Meenakshi Singh (1645396), Yogesh P. Bharitkar (649975), Ramkrishna Mandal (6536510), Abhijit Hazra (385320), V. Ravichandiran (3864802), Amrutha A.V. Krishnan (6536513)   +6 more
core   +1 more source

Withaferin A promotes proliferation and migration of brain endothelial cells

, 2016
Purpose: To investigate the effect of withaferin A (WFA) on the proliferation and migration of brain endothelial cells.Methods: BALB-5023 mouse microvascular cells were treated with a range of withaferin A (WFA) concentrations from 10 to 100 ng/mL ...
Huang, Li-An, Li, Tong, Wang, Zi-Jun, Jiang, Shan   +3 more
core   +2 more sources

Withaferin A and Alzheimer\u27s Disease: A Review [PDF]

Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
core  

Nanoencapsulation of Withaferin-A for the Treatment of Neurological Disorder

, 2022
A better delivery mechanism is ensured by a superior formulation. This study is based on the fact that people believe in natural products more than chemical products.
Sonu Sharma, Dr. Viney Lather, Dr. Vikram Sharma
core   +1 more source

PROTECTIVE EFFECT OF WITHAFERIN-A ON MICRONUCLEUS FREQUENCY AND DETOXICATION AGENTS DURING EXPERIMENTAL ORAL CARCINOGENESIS

, 2008
Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, K., Manoharan, S., Nirmal, M. R., Alias, L. M., Suresh, K., Balakrishnan, S., Senthil, N.   +6 more
core   +1 more source

Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

Neural Plasticity, 2015
Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. Yet, their contribution to these processes remains mostly elusive. Astroglia
Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Journal of Chemistry
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and ...
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal   +10 more
doaj   +1 more source