Results 91 to 100 of about 102,615,988 (206)
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen +7 more
wiley +1 more source
Nanoencapsulation of Withaferin-A for the Treatment of Neurological Disorder [PDF]
, 2022 A better delivery mechanism is ensured by a superior formulation. This study is based on the fact that people believe in natural products more than chemical products.
Sonu Sharma, Dr. Viney Lather, Dr. Vikram Sharma
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Effect of withanone and withaferin A purified from WSWE on S. globosa cells.
, 2022 [A, B] Mirror HPLC chromatograms of standard mix (black) and purified withanone (blue) (A)/withaferin A (B) recorded at 227 nm. [C, D] Dose response curves of withanone (A) and withaferin A (B) demonstrating anti-sporotrichotic effects against S. globosa
Acharya Balkrishna (5640038) +5 more
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Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella +4 more
wiley +1 more source
Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice
, 2018 The increasing global prevalence of obesity and its associated disorders point to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss.
Lee, Jaemin +7 more
core +1 more source
The development of advanced high-capacity nanoparticle-based drug loading, precise targeting, low toxicity, and excellent biocompatibility is critical for improving cancer therapeutics.
Paulraj Arunkumar +2 more
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Chemical structures of withanone and withaferin A.
, 2013 Withanone is a C6, C7 epoxy compound (colored red) that has hydroxyl groups (colored green) on C5 and C17. On the other hand, withaferin A is a C5, C6 epoxy compound (colored red) with hydroxyl groups on C4 and C27 (colored green).
M. Uthayakumar (308967) +9 more
core +1 more source
Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
, 2023 Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017) +3 more
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PROTECTIVE EFFECT OF WITHAFERIN-A ON MICRONUCLEUS FREQUENCY AND DETOXICATION AGENTS DURING EXPERIMENTAL ORAL CARCINOGENESIS [PDF]
, 2008 Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, K. +6 more
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Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach
, 2019 To cope with the poor aqueous solubility of withaferin A, a broad-spectrum anti-cancer agent effective against therapy-resistant cancers, a polymer-drug conjugate was synthesized via a grafting-from-drug approach.
Vanden Berghe, Tom +8 more
core +1 more source