Results 131 to 140 of about 3,279 (167)
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Effect of Withaferin A on cells in tissue culture
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1973The experiments were performed with embryonal chicken fibroblasts, HeLa cells and H. Ep. 2 (human larynx carcinoma) in hanging drop cultures. They confirm the results obtained with tumor bearing mice. Withaferin A is acting as a mitotic poison and arrests the tumor cells at metaphase. Its effect on cells may be compared to that of colchicine, alkaloids
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Steroids, 1982
Microbial transformation experiments were conducted with the antitumor lactone withaferin-A. Cunninghamella elegans NRRL 1393 transformed withaferin-A (1a) to 15 beta-hydroxywithaferin-A (2a) and 12 beta-hydroxy-withaferin-A (3a). The hydroxylated metabolites were isolated by solvent extraction and were purified by column and thin-layer chromatography.
J, Fuska +3 more
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Microbial transformation experiments were conducted with the antitumor lactone withaferin-A. Cunninghamella elegans NRRL 1393 transformed withaferin-A (1a) to 15 beta-hydroxywithaferin-A (2a) and 12 beta-hydroxy-withaferin-A (3a). The hydroxylated metabolites were isolated by solvent extraction and were purified by column and thin-layer chromatography.
J, Fuska +3 more
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Production of Withaferin A in Shoot Cultures of Withania somnifera
Planta Medica, 2001Multiple shoot cultures of Withania somnifera were established from single shoot tip explants and their potential for the production of two principle withanolides, withaferin A and withanolide D was investigated. Shoot tips grown on MS medium supplemented with BA (1 mg l(-1)) induced 10.0 +/- 1.15 microshoots per explants and shoot cultures accumulated
S, Ray, S, Jha
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Reactions of withaferin-A with model biological nucleophiles
Bioorganic Chemistry, 1976Abstract Withaferin-A was reacted with three model biological nucleophiles: ethyl mercaptan, thiophenol, and l -cysteine ethyl ester. Under neutral or alkaline conditions, each of the thiols underwent facile Michael addition with the antitumor agent.
Allan W. Nicholas, John P. Posazza
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Journal of the Chemical Society B: Physical Organic, 1968
X-Ray crystal-structure analysis of withaferin A acetate p-bromobenzoate, C37H43BrO8, has established the constitution and absolute stereochemistry of withaferin A, a novel tumour-inhibiting 5β-steroidal lactone isolated from Acnistus arborescens. The crystals are orthorhombic, of space group P212121, with eight molecules of the p-bromobenzoate and ...
A. T. McPhail, G. A. Sim
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X-Ray crystal-structure analysis of withaferin A acetate p-bromobenzoate, C37H43BrO8, has established the constitution and absolute stereochemistry of withaferin A, a novel tumour-inhibiting 5β-steroidal lactone isolated from Acnistus arborescens. The crystals are orthorhombic, of space group P212121, with eight molecules of the p-bromobenzoate and ...
A. T. McPhail, G. A. Sim
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Biotransformation of withaferin-a by a culture ofArthrobacter simplex
Folia Microbiologica, 1985Arthrobacter simplex biotransformed withaferin-A under submerged conditions to 7 new derivatives while 4,27-di-O-acetylwithaferin-A was transformed to another 9 derivatives. The melting point of all these substances was determined, along with RF values and colour reactions with 4-anisaldehyde reagent.
J. Funska +4 more
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Preliminary study on the synthesis of withaferin A.
1968This item was digitized as part of a project to share McGill's intellectual legacy with the public. If you are the copyright holder or a relative of the copyright holder who is deceased, you may request withdrawal by emailing escholarship.library@mcgill.ca.
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Response of a Mouse Fibrosarcoma to Withaferin A and Radiation
Pharmacy and Pharmacology Communications, 1999The in-vivo growth response of a transplantable mouse AEbrosarcoma to withaferin A, a plant steroidal lactone, with or without local gamma radiation, was studied. Solid tumours were obtained by injecting 5 6 10 5 tumour cells on the dorsal skin of adult Swiss albino mice.
R. Kamath, B.S.S. Rao, P.U. Devi
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Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect
Food and Chemical Toxicology, 2023Haoyang Zou
exaly