Results 111 to 120 of about 118,549,391 (165)

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Effect of withanone and withaferin A on proliferation of human normal and cancer cells.

, 2013
(A) Morphology of the human normal (TIG) and cancer (U2OS) cells treated with different concentrations of withaferin A (Wi-A) and withanone (Wi-N). (B) MTT assay of control, Wi-A and Wi-N treated normal and cancer cells.
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
core   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Effect of pre-soaking, Vcom and Vcom-L application on the content of Withaferin A, Withanolide A and Withanone in leaves of W. somnifera.

, 2018
Effect of pre-soaking, Vcom and Vcom-L application on the content of Withaferin A, Withanolide A and Withanone in leaves of W. somnifera.
Puja Ohri (5104871), Sunil C. Kaul (186002), Jia Wang (51945), Amandeep Kaur (572773), Baldev Singh (805353), Pratap Kumar Pati (701890), Renu Wadhwa (185998), Arvinder Kaur (5104874)   +7 more
core   +1 more source

Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells

Cancer Cell International
Background Epigenetic phytochemicals are considered as an efficacious and safe alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions enable simultaneously targeting various neoplastic pathways to eradicate multiple
Mohammad Mijanur Rahman, Trygve O. Tollefsbol   +1 more
doaj   +1 more source

Withaferin a suppresses the expression of vascular endothelial growth factor in ehrlich ascites tumor cells via sp1 transcription factor

, 2009
In the ayurvedic system of medicine, the medicinal plant, Withania somnifera Dunal (Solanaceae) finds application for numerous ailments including cancer.
Bharathi P. Salimath, Prasanna Kumar, S., Shilpa, P.   +2 more
core  

Discovery of MYC/NSD3S Protein-Protein Interaction Negative Modulators with a Live Cell Nanoluciferase Protein-Fragment Complementation uHTS Assay. [PDF]

ACS Omega
Vera-Molina S, Acosta-Yanez D, Olivera E, Romero-Vera E, Farkas C, Hepp MI, Salas-Burgos A, Du Y, Gonzalez-Pecchi V.   +8 more
europepmc   +1 more source

Pan-cancer profiles of mesothelin (MSLN) unveil diagnostic potential and therapeutic targetability of pancreatic adenocarcinoma. [PDF]

PLoS One
Sheikh MR, Mistry B, Shafin RH, Apu A, Sara TH, Tasnim J, Dutta D, Nandy A, Rahman A.   +8 more
europepmc   +1 more source

Withaferin A and Alzheimer\u27s Disease: A Review [PDF]

Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
core  

Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells. [PDF]

ACS Appl Mater Interfaces
Karimi A, Golchin H, Adamec M, Stanik A, Nandakumar P, Ganesan M, Aga M, White E, Kelley MJ, Acott T.   +9 more
europepmc   +1 more source