Results 101 to 110 of about 102,615,988 (206)

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Molecular Cancer, 2010
Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah, Zhokhov Sergey, Palagani Ajay, Poompimon Wilart, Mankhetkorn Samlee, Suttana Wipob, Haegeman Guy, Berghe Wim   +7 more
doaj   +1 more source

Data from SILAC-based quantitative analysis of lysates from mouse microglial cells treated with Withaferin A (WA)

Data in Brief, 2016
Mass spectrometry data collected in a study analyzing the effect of withaferin A (WA) on a mouse microglial (N9) cell line is presented in this article.
Malathi Narayan, Kent W. Seeley, Umesh K. Jinwal   +2 more
doaj   +1 more source

Withaferin-A: A Potential Anticancer Withanolide from \u3cem\u3eWithania somnifera\u3c/em\u3e (L.) Dun. [PDF]

, 2005
Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders.
Singh, Amrit Pal
core  

Withaferin A decreases glycolytic reprogramming in breast cancer

Scientific Reports
Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan, Asad ur Rehman, Shumaila Siddiqui, Jiyauddin Khan, Sheersh Massey, Prithvi Singh, Daman Saluja, Syed Akhtar Husain, Mohammad Askandar Iqbal   +8 more
openaire   +3 more sources

Withaferin A and Alzheimer\u27s Disease: A Review [PDF]

Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
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Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction

, 2019
A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition.
Yogita H. Dahat (6536516), Meenakshi Singh (1645396), Yogesh P. Bharitkar (649975), Ramkrishna Mandal (6536510), Abhijit Hazra (385320), V. Ravichandiran (3864802), Amrutha A.V. Krishnan (6536513)   +6 more
core   +1 more source

Glioblastoma Stem Cells and Withaferin A, A Review [PDF]

Biomedical Journal of Scientific & Technical Research, 2019
Glioblastoma multiforme is characterized by tumor cell heterogeneity, and by recurrent invasive tumors following conventional radiation, cytotoxic drugs, and limited ablative surgery [1-5]...
openaire   +1 more source

Protective role of Withaferin-a on red blood cell integrity during 7,12-dimethylbenz[A]anthracene induced oral carcinogenesis [PDF]

, 2010
The aim of the present study was to investigate the protective effect of Withaferin-A on red blood cell integrity during 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis.
Vellaichamy, J, L Alias, K Rajalingam, Panjamurthy, K, Rajalingam, K, Alias, L, K Panjamurthy, P Pugalendi, J Vellaichamy, Manoharan, S, S Balakrishnan, Balakrishnan, S, S Manoharan, Pugalendi, P   +13 more
core   +1 more source

Implications of Withaferin A in neurological disorders

Neural Regeneration Research, 2020
Natasha Ram, Stephanie L. Peak, Andres R. Perez, Umesh K. Jinwal   +3 more
openaire   +3 more sources

Apoptosis is Induced in leishmanial Cells by a Novel Protein Kinase Inhibitor Withaferin A and is Facilitated by Apoptotic Topoisomerase I–DNA complex

, 2007
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. We report here that like staurosporine, withaferin A is a potent inhibitor of PKC.
Sen, T, Pramanik, S, Mukhopadhyay, S, Mukhopadhyay, S., H K Majumder, Sen, T., B Banerjee, Das, B. B., Banerjee, B, S Mukhopadhyay, Majumder, H. K., N Sen, Sen, N., B B Das, A Ganguly, Banerjee, B., Ganguly, A., Majumder, Hemanta K, Sen, N, Pramanik, S., Ganguly, A, T Sen, S Pramanik   +22 more
core   +1 more source