Plant-Derived Agents and Systemic Sclerosis: A Systematic Review of Therapeutic Potential and Molecular Mechanisms. [PDF]
Ilie CM +3 more
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Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis. [PDF]
Zhu X, Zeng Q, Lei Y, Xu D.
europepmc +1 more source
Ashwagandha (<i>Withania somnifera</i>) Plant Extracts Affect the Cytochrome P450 System and Cytotoxicity of Primary Human Hepatocytes. [PDF]
McDonald KL +15 more
europepmc +1 more source
Preclinical Evidence of <i>Withania somnifera</i> and <i>Cordyceps</i> spp.: Neuroprotective Properties for the Management of Alzheimer's Disease. [PDF]
Tancreda G +3 more
europepmc +1 more source
Pharmacological Insights Into Ashwagandha (Withania somnifera): A Review of Its Immunomodulatory and Neuroprotective Properties. [PDF]
Dipankar SP +5 more
europepmc +1 more source
Natural Products Targeting BCR-ABL: A Plant-Based Approach to Chronic Myeloid Leukemia Treatment. [PDF]
Pechlivani L +4 more
europepmc +1 more source
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Cytotoxic screening and antibacterial activity of Withaferin A
Journal of Toxicology and Environmental Health, Part A, 2022Cancer and bacterial infections are among the leading causes of death worldwide. Plant-derived bioactive compounds constitute promising alternatives for development of new therapeutics. This study aimed at evaluating the biological activity of Withaferin A using 6 tumor cell lines: A549 (lung cancer), U87MG (glioblastoma), SH-SY5Y (neuroblastoma), B16 ...
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Withaferin A: From Ancient Remedy to Potential Drug Candidate [PDF]
Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in research, owning to its multidimensional biological properties. It is an abundant constituent in Withania somnifera Dunal. (Ashwagandha, WS) that is one of the prehistoric pivotal remedies in Ayurveda.
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Microbiological and chemical dehydrogenation of withaferin A
Folia Microbiologica, 1987Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized
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