Results 111 to 120 of about 81,875,801 (209)

Efficacy of Withania somnifera chemotypes NMITLI – 101R, 118R and Withaferin A against experimental visceral leishmaniasis

, 2014
The immunoprophylactic and therapeutic potentials of root extracts of Withania somnifera chemotypes (NMITLI-118, NMITLI-101) and pure withanolide–withaferin A was investigated against Leishmania donovani infection in hamsters.The naive animals, fed ...
A. Dube, S. Misra Bhattacharya, MANDAL, C, MISRA BHATTACHARYA, S, R. Gupta, TRIPATHI, C. D. P, GUPTA, R, KUSHAWAHA, P. K, Dube, A, C. Mandal, C. D. P. Tripathi, P. K. Kushawaha   +11 more
core   +1 more source

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Mortalin, a target of withanone and withaferin A.

, 2013
Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) in the “latch region” of mortalin (PDB-id: 3N8E). (C) Quantitative analysis of mortalin in human cancer (U2OS) cells treated with various doses of Wi-N and Wi-A. (D) Imaging of mortalin in human
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
core   +1 more source

Radiosensitization of a mouse melanoma by withaferin A: In vivo studies

, 2000
432-437The radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo.Treatment of 100 mm3 tumours with 10 to 60 mg/kg withaferin A intraperitoneally produced a dose dependent increase in growth delay
Rao, B S Satish, Devi, P Uma, Kamath, Ravindra   +2 more
core  

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Withaferin-A: A Potential Anticancer Withanolide from \u3cem\u3eWithania somnifera\u3c/em\u3e (L.) Dun.

, 2005
Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders.
Singh, Amrit Pal
core   +1 more source

Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters

, 2009
16-23With an aim to investigate the protective effect of Withaferin-A on 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis in Syrian golden hamsters, tumour incidence, tumour volume and tumour burden and status of detoxication agents ...
Manoharan, S, Alias, Linsa Mary, Menon, Venugopal P, Balakrishnan, S, Panjamurthy, K   +4 more
core  

NRF2, a target of withanone and withaferin A.

, 2013
Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) with Nrf-2 (PDB-id: 2FLU), and Western blot analysis of Nrf2 in U2OS cells treated with Wi-A and Wi-N (C). (D) Detection of Nrf2 in the nuclear and cytosolic fractions of cells treated with Wi-A
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
core   +1 more source

Withaferin-A: A Potential Anticancer Withanolide from Withania somnifera (L.) Dun.

, 2003
Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders.
Singh, Amrit Pal
core   +1 more source

Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential

, 2011
Regio-/stereoselective Michael addition to ring A of withaferin-A was performed using an optimized reaction procedure to synthesise a library of 2,3-dihydro,3- -substituted withaferin-A derivatives. The analogues thus obtained were evaluated for in vitro
Debaraj Mukherjee, Saxsena, A.K., Rabiya Majeed, Yousuf, Syed Khalid, Syed Khalid Yousuf, Majeed, Rabiya, Purnima, Basant, K.A. Suri, Sangwan, Payare lal, Payare lal Sangwan, Ahmad, Mudassier, Taneja, Subhash Chandra, Suri, K.A., Mukherjee, Debaraj, Mudassier Ahmad, A.K. Saxsena, Basant Purnima, Subhash Chandra Taneja   +17 more
core   +1 more source