Results 91 to 100 of about 3,274 (173)

Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

Neural Plasticity, 2015
Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. Yet, their contribution to these processes remains mostly elusive. Astroglia
Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Implications of Withaferin A in neurological disorders

Neural Regeneration Research, 2020
Natasha Ram, Stephanie L. Peak, Andres R. Perez, Umesh K. Jinwal   +3 more
openaire   +3 more sources

Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells

Cancer Cell International
Background Epigenetic phytochemicals are considered as an efficacious and safe alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions enable simultaneously targeting various neoplastic pathways to eradicate multiple
Mohammad Mijanur Rahman, Trygve O. Tollefsbol   +1 more
doaj   +1 more source

New Vistas for Withania somnifera in Signal Transduction of Inflammation and Aging. [PDF]

Pharm Res
Sharma E, Mehta D, Muthuraj P, Panda S, Ajgaonkar S, Maniar D, Biju A, Nair S.   +7 more
europepmc   +1 more source

Combined Effects of Withaferin A and Sodium Butyrate on NF-κB Signaling and Epigenetic Regulation in Breast Cancer Cells. [PDF]

Nutrients
Witt BL, Singaravelan N, Tollefsbol TO.
europepmc   +1 more source

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress. [PDF]

Int J Mol Med
Xue M, Feng J, Mao X.
europepmc   +1 more source

Molecular docking analysis of DprE1 from <i>M. tuberculosis</i> with phytochemicals. [PDF]

Bioinformation
Raja J, Blessy JJ.
europepmc   +1 more source