Results 121 to 130 of about 113,931,576 (202)

Mortalin, a target of withanone and withaferin A.

, 2013
Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) in the “latch region” of mortalin (PDB-id: 3N8E). (C) Quantitative analysis of mortalin in human cancer (U2OS) cells treated with various doses of Wi-N and Wi-A. (D) Imaging of mortalin in human
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
core   +1 more source

Efficacy of Withania somnifera chemotypes NMITLI – 101R, 118R and Withaferin A against experimental visceral leishmaniasis

, 2014
The immunoprophylactic and therapeutic potentials of root extracts of Withania somnifera chemotypes (NMITLI-118, NMITLI-101) and pure withanolide–withaferin A was investigated against Leishmania donovani infection in hamsters.The naive animals, fed ...
A. Dube, S. Misra Bhattacharya, MANDAL, C, MISRA BHATTACHARYA, S, R. Gupta, TRIPATHI, C. D. P, GUPTA, R, KUSHAWAHA, P. K, Dube, A, C. Mandal, C. D. P. Tripathi, P. K. Kushawaha   +11 more
core   +1 more source

Withaferin a suppresses the expression of vascular endothelial growth factor in ehrlich ascites tumor cells via sp1 transcription factor

, 2009
In the ayurvedic system of medicine, the medicinal plant, Withania somnifera Dunal (Solanaceae) finds application for numerous ailments including cancer.
Bharathi P. Salimath, Prasanna Kumar, S., Shilpa, P.   +2 more
core  

Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters

, 2009
16-23With an aim to investigate the protective effect of Withaferin-A on 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis in Syrian golden hamsters, tumour incidence, tumour volume and tumour burden and status of detoxication agents ...
Manoharan, S, Alias, Linsa Mary, Menon, Venugopal P, Balakrishnan, S, Panjamurthy, K   +4 more
core  

Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells

Cancer Cell International
Background Epigenetic phytochemicals are considered as an efficacious and safe alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions enable simultaneously targeting various neoplastic pathways to eradicate multiple
Mohammad Mijanur Rahman, Trygve O. Tollefsbol   +1 more
doaj   +1 more source

Pan-cancer profiles of mesothelin (MSLN) unveil diagnostic potential and therapeutic targetability of pancreatic adenocarcinoma. [PDF]

PLoS One
Sheikh MR, Mistry B, Shafin RH, Apu A, Sara TH, Tasnim J, Dutta D, Nandy A, Rahman A.   +8 more
europepmc   +1 more source

Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells. [PDF]

ACS Appl Mater Interfaces
Karimi A, Golchin H, Adamec M, Stanik A, Nandakumar P, Ganesan M, Aga M, White E, Kelley MJ, Acott T.   +9 more
europepmc   +1 more source

Withanolides Are Detected in Human Urine Following Oral Administration of a <i>Withania somnifera</i> Product. [PDF]

Int J Mol Sci
Speers AB, Limoico ED, Lozano-Ortiz A, Marney L, Choi J, Barr SA, Williamson RT, Strangman WK, Maier CS, Soumyanath A.   +9 more
europepmc   +1 more source

Nutraceutical Applications of <i>Withania somnifera</i>: The Scientific Knowledge for Rational Modern Use of the "Ayurvedic Adaptogen". [PDF]

Foods
Pandey S, Pant P, Corbioli G, Bonazzi E, Cisneros-Yupanqui M, Salmaso P, Dall'Acqua S.   +6 more
europepmc   +1 more source

Combined Effects of Withaferin A and Sodium Butyrate on NF-κB Signaling and Epigenetic Regulation in Breast Cancer Cells. [PDF]

Nutrients
Witt BL, Singaravelan N, Tollefsbol TO.
europepmc   +1 more source