Results 101 to 110 of about 113,931,576 (202)
The development of advanced high-capacity nanoparticle-based drug loading, precise targeting, low toxicity, and excellent biocompatibility is critical for improving cancer therapeutics.
Paulraj Arunkumar +2 more
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Chemical structures of withanone and withaferin A.
, 2013 Withanone is a C6, C7 epoxy compound (colored red) that has hydroxyl groups (colored green) on C5 and C17. On the other hand, withaferin A is a C5, C6 epoxy compound (colored red) with hydroxyl groups on C4 and C27 (colored green).
M. Uthayakumar (308967) +9 more
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Effect of withanone and withaferin A purified from WSWE on S. globosa cells.
, 2022 [A, B] Mirror HPLC chromatograms of standard mix (black) and purified withanone (blue) (A)/withaferin A (B) recorded at 227 nm. [C, D] Dose response curves of withanone (A) and withaferin A (B) demonstrating anti-sporotrichotic effects against S. globosa
Acharya Balkrishna (5640038) +5 more
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PROTECTIVE EFFECT OF WITHAFERIN-A ON MICRONUCLEUS FREQUENCY AND DETOXICATION AGENTS DURING EXPERIMENTAL ORAL CARCINOGENESIS [PDF]
, 2008 Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, K. +6 more
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Molecular Cancer, 2010 Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah +7 more
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Data in Brief, 2016 Mass spectrometry data collected in a study analyzing the effect of withaferin A (WA) on a mouse microglial (N9) cell line is presented in this article.
Malathi Narayan +2 more
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Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach
, 2019 To cope with the poor aqueous solubility of withaferin A, a broad-spectrum anti-cancer agent effective against therapy-resistant cancers, a polymer-drug conjugate was synthesized via a grafting-from-drug approach.
Vanden Berghe, Tom +8 more
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Withaferin A and Alzheimer\u27s Disease: A Review [PDF]
Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
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Withaferin A decreases glycolytic reprogramming in breast cancer
Scientific ReportsReprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan +8 more
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Withaferin-A: A Potential Anticancer Withanolide from Withania somnifera (L.) Dun. [PDF]
, 2003 Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders.
Singh, Amrit Pal
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