Results 41 to 50 of about 113,931,576 (202)
Metabolites, 2022 This study aimed at optimizing conditions for increased withanolide production in Withania somnifera. The elicitors used for the foliar spray on the aerial parts of the plant were salicylic acid, jasmonic acid, and chitosan for the enhancement of ...
Manali Singh +9 more
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Withaferin-A compound targeting α-amylase Suppl.files
, 2022 Withaferin-A compound targeting α ...
Aziz Unnisa
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Scientific Reports, 2021 Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa +8 more
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Development of withaferin A analogs as probes of angiogenesis [PDF]
Bioorganic & Medicinal Chemistry Letters, 2006 The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin-proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angiogenesis.
Yasuno, Yokota +4 more
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Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol +5 more
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Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel +6 more
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, 2022 Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine.
Winssinger, Nicolas +2 more
core +1 more source
Frontiers in Pharmacology, 2018 Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale +3 more
doaj +1 more source
Protective effect of Withaferin-A on micronucleus frequency and detoxication agents during experimental oral carcinogenesis [PDF]
, 2010 Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency andbuccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
N Senthil +13 more
core +1 more source
Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
Aging, 2021 Withanolides are a class of compounds usually found in plant extracts which are an attractive geroprotective drug design starting point. We evaluated the geroprotective properties of Withaferin A (WA) in vivo using the Drosophila model. Flies were supplemented by nutrient medium with WA (at a concentration of 1, 10, or 100 μM dissolved in ethanol) for ...
Koval, Liubov +4 more
openaire +2 more sources