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Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation.

Blood
Stewart J, Damania B.
europepmc   +1 more source

Withaferin A: From Ancient Remedy to Potential Drug Candidate [PDF]

Molecules, 2021
Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in research, owning to its multidimensional biological properties. It is an abundant constituent in Withania somnifera Dunal. (Ashwagandha, WS) that is one of the prehistoric pivotal remedies in Ayurveda.
Ihsan-Ul Haq, Hamada Abdelgawad, Mohammad K Okla   +2 more
exaly   +5 more sources

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Cytotoxic screening and antibacterial activity of Withaferin A

Journal of Toxicology and Environmental Health, Part A, 2022
Cancer and bacterial infections are among the leading causes of death worldwide. Plant-derived bioactive compounds constitute promising alternatives for development of new therapeutics. This study aimed at evaluating the biological activity of Withaferin A using 6 tumor cell lines: A549 (lung cancer), U87MG (glioblastoma), SH-SY5Y (neuroblastoma), B16 ...
Altevir, Rossato Viana, B, Godoy Noro, J C, Lenz, M, Luiza Machado Teixeira, M, Bolson Serafin, R, Hörner, C, Franco, L, Maria Fontanari Krause, B, Stefanello Vizzotto, B, Jalfim Maraschin   +9 more
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Molecular insight in the multifunctional activities of Withaferin A

Biochemical Pharmacology, 2012
Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities.
Wim Vanden Berghe, Mary Kaileh, Karen Heyninck   +2 more
exaly   +4 more sources

Microbiological and chemical dehydrogenation of withaferin A

Folia Microbiologica, 1987
Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized
J, Fuska, B, Proska, J, Williamson, J P, Rosazza   +3 more
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The effect of withaferin A on plant cells

European Journal of Cancer (1965), 1971
Abstract Withaferin A in a concentration of 0·01-0·5% in water inhibited the growth of Allium cepa roots. Furthermore, withaferin A induced c-tumor formation and lateral root formation on treated roots. Microscopical examination of withaferin A-treated root tip cells showed a clear arrest at metaphase as soon as 2 hr after treatment.
B, Shohat, H, Joshua
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Withaferin A is a potent inhibitor of angiogenesis

Angiogenesis, 2004
The medicinal plant Withania somnifera is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. In Ayurveda , the major Traditional Indian medicine system, extracts from W. somnifera are distinctively employed for the treatment of arthritis and menstrual disorders.
Royce, Mohan, Hans J, Hammers, Paola, Bargagna-Mohan, Xiaoguo H, Zhan, Christopher J, Herbstritt, Antonio, Ruiz, Li, Zhang, Art D, Hanson, Barry P, Conner, John, Rougas, Victor S, Pribluda   +10 more
openaire   +2 more sources

Antiplatelet, anticoagulant, and profibrinolytic activities of withaferin A

Vascular Pharmacology, 2014
Withaferin A (WFA), an active compound from Withania somnifera, is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. However, antiplatelet, anticoagulant, and profibrinolytic properties of WFA have not been studied.
Sae-Kwang, Ku, Jong-Sup, Bae
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The Use of Withaferin A to Study Intermediate Filaments

2016
Withaferin A (WFA), initially identified as a compound that inhibits experimental angiogenesis, has been shown to bind to soluble vimentin (sVim) and other type III intermediate filament (IF) proteins. We review WFA's dose-related activities (Section 1), examining nanomolar concentrations effects on sVim in cell proliferation and submicromolar effects ...
Royce, Mohan, Paola, Bargagna-Mohan
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Withaferin A and its potential role in glioblastoma (GBM)

Journal of Neuro-Oncology, 2016
Within the Ayurvedic medical tradition of India, Ashwagandha (Withania somnifera) is a well-known herb. A large number of withanolides have been isolated from both its roots and its leaves and many have been assessed for their pharmacological activities. Amongst them, Withaferin A is one of its most bioactive phytoconstituents.
Jasdeep, Dhami, Edwin, Chang, Sanjiv S, Gambhir   +2 more
openaire   +2 more sources