Results 131 to 140 of about 3,275 (173)

Antiplatelet, anticoagulant, and profibrinolytic activities of withaferin A

Vascular Pharmacology, 2014
Withaferin A (WFA), an active compound from Withania somnifera, is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. However, antiplatelet, anticoagulant, and profibrinolytic properties of WFA have not been studied.
Sae-Kwang, Ku, Jong-Sup, Bae
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The Use of Withaferin A to Study Intermediate Filaments

2016
Withaferin A (WFA), initially identified as a compound that inhibits experimental angiogenesis, has been shown to bind to soluble vimentin (sVim) and other type III intermediate filament (IF) proteins. We review WFA's dose-related activities (Section 1), examining nanomolar concentrations effects on sVim in cell proliferation and submicromolar effects ...
Royce, Mohan, Paola, Bargagna-Mohan
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Withaferin A and its potential role in glioblastoma (GBM)

Journal of Neuro-Oncology, 2016
Within the Ayurvedic medical tradition of India, Ashwagandha (Withania somnifera) is a well-known herb. A large number of withanolides have been isolated from both its roots and its leaves and many have been assessed for their pharmacological activities. Amongst them, Withaferin A is one of its most bioactive phytoconstituents.
Jasdeep, Dhami, Edwin, Chang, Sanjiv S, Gambhir   +2 more
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Effect of Withaferin A on cells in tissue culture

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1973
The experiments were performed with embryonal chicken fibroblasts, HeLa cells and H. Ep. 2 (human larynx carcinoma) in hanging drop cultures. They confirm the results obtained with tumor bearing mice. Withaferin A is acting as a mitotic poison and arrests the tumor cells at metaphase. Its effect on cells may be compared to that of colchicine, alkaloids
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Microbial transformations of natural antitumor agents. 23. conversion of withaferin-A to 12β- and 15β-hydroxy derivatives of withaferin-A.

Steroids, 1982
Microbial transformation experiments were conducted with the antitumor lactone withaferin-A. Cunninghamella elegans NRRL 1393 transformed withaferin-A (1a) to 15 beta-hydroxywithaferin-A (2a) and 12 beta-hydroxy-withaferin-A (3a). The hydroxylated metabolites were isolated by solvent extraction and were purified by column and thin-layer chromatography.
J, Fuska, J, Prousek, J, Rosazza, M, Budesinsky   +3 more
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Production of Withaferin A in Shoot Cultures of Withania somnifera

Planta Medica, 2001
Multiple shoot cultures of Withania somnifera were established from single shoot tip explants and their potential for the production of two principle withanolides, withaferin A and withanolide D was investigated. Shoot tips grown on MS medium supplemented with BA (1 mg l(-1)) induced 10.0 +/- 1.15 microshoots per explants and shoot cultures accumulated
S, Ray, S, Jha
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Reactions of withaferin-A with model biological nucleophiles

Bioorganic Chemistry, 1976
Abstract Withaferin-A was reacted with three model biological nucleophiles: ethyl mercaptan, thiophenol, and l -cysteine ethyl ester. Under neutral or alkaline conditions, each of the thiols underwent facile Michael addition with the antitumor agent.
Allan W. Nicholas, John P. Posazza
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Molecular conformations. Part VI. The structure of withaferin A: X-ray analysis of withaferin A acetate p-bromobenzoate

Journal of the Chemical Society B: Physical Organic, 1968
X-Ray crystal-structure analysis of withaferin A acetate p-bromobenzoate, C37H43BrO8, has established the constitution and absolute stereochemistry of withaferin A, a novel tumour-inhibiting 5β-steroidal lactone isolated from Acnistus arborescens. The crystals are orthorhombic, of space group P212121, with eight molecules of the p-bromobenzoate and ...
A. T. McPhail, G. A. Sim
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Biotransformation of withaferin-a by a culture ofArthrobacter simplex

Folia Microbiologica, 1985
Arthrobacter simplex biotransformed withaferin-A under submerged conditions to 7 new derivatives while 4,27-di-O-acetylwithaferin-A was transformed to another 9 derivatives. The melting point of all these substances was determined, along with RF values and colour reactions with 4-anisaldehyde reagent.
J. Funska, A. Khandlová, M. Šturdíková, J. P. Rosazza, K. Kieslich   +4 more
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Preliminary study on the synthesis of withaferin A.

1968
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